Evidence map›Paper›PMID 32887739›Full record

ArticleThorax2020

Lesson of the month: novel method to quantify neutrophil uptake in early lung cancer using SPECT-CT.

Neda Farahi, Daniel Gillett, Mark Southwood, Doris Rassl, Nicola Tregay, Uta Hill, Stephen Denis Preston, Chrystalla Loutsios, Laurence Si Chong Lok, Sarah Heard and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thorax, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Retention ofACS infectious diseases · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Neda FarahiDepartment of Medicine, University of Cambridge, Cambridge, UK nf231@medschl.cam.ac.uk.
Daniel GillettDepartment of Nuclear Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Mark SouthwoodDepartment of Pathology, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK.
Doris RasslDepartment of Pathology, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK.
Nicola TregayDepartment of Medicine, University of Cambridge, Cambridge, UK.
Uta HillCambridge Centre for Lung Infection, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK.
Stephen Denis PrestonDepartment of Pathology, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK.ORCID 0000-0002-6836-3591
Chrystalla LoutsiosDepartment of Medicine, University of Cambridge, Cambridge, UK.
Laurence Si Chong LokDepartment of Medicine, University of Cambridge, Cambridge, UK.
Sarah HeardDepartment of Nuclear Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
John BuscombeDepartment of Nuclear Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Robert Campbell RintoulDepartment of Thoracic Oncology, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK.ORCID 0000-0003-3875-3780
A Michael PetersDepartment of Nuclear Medicine, King's College Hospital NHS Foundation Trust, London, UK.
Charlotte SummersDepartment of Medicine, University of Cambridge, Cambridge, UK.
Edwin R ChilversNational Heart and Lung Institute, Imperial College, London, UK.ORCID 0000-0002-4230-9677
University of Cambridge · GBPapworth Hospital NHS Foundation Trust · GBCambridge University Hospitals NHS Foundation Trust · GBImperial College London · GBKing's College Hospital NHS Foundation Trust · GB

Funding

Medical Research Council MR/J00345X/1Wellcome Trust
6 · The paper itself

Abstract

Neutrophils play an important role in the lung tumour microenvironment. We hypothesised that radiolabelled neutrophils coupled to single-photon emission CT (SPECT) may non-invasively quantify neutrophil uptake in tumours from patients with non-small cell lung cancer. We demonstrated increased uptake of radiolabelled neutrophils from the blood into tumours compared with non-specific uptake using radiolabelled transferrin. Moreover, indium-111-neutrophil activity in the tumour biopsies also correlated with myeloperoxidase (MPO)-positive neutrophils. Our data support the utility of imaging with In-111-labelled neutrophils and SPECT-CT to quantify neutrophil uptake in lung cancer.

Indexed as

NeutrophilsTomography, Emission-Computed, Single-PhotonAdultBiopsyFemaleHumansIndium RadioisotopesLung NeoplasmsMaleNeoplasm StagingIndium-111Indium Radioisotopesimaging/CT MRI etclung cancerneutrophil biology

Identifiers

PMID32887739
PMCPMC7569370
OpenAlexW3083218333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.