Evidence map›Paper›PMID 32887735›Full record

ArticlemBio2020

An Early Pandemic Analysis of SARS-CoV-2 Population Structure and Dynamics in Arizona.

Jason T Ladner, Brendan B Larsen, Jolene R Bowers, Crystal M Hepp, Evan Bolyen, Megan Folkerts, Krystal Sheridan, Ashlyn Pfeiffer, Hayley Yaglom, Darrin Lemmer and 13 more

Abstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. VGsim: scalable viral genealogy simulator for global pandemic.medRxiv : the preprint server for health sciences · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. One year into the pandemic: Short-term evolution of SARS-CoV-2 and emergence of new lineages.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Jason T Ladner *Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.
Brendan B Larsen *Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, USA.
Jolene R Bowers *Pathogen and Microbiome Division, Translational Genomics Research Institute, Flagstaff, Arizona, USA.
Crystal M Hepp *Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.ORCID 0000-0002-0612-3648
Evan BolyenCenter for Applied Microbiome Science, Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.
Megan FolkertsPathogen and Microbiome Division, Translational Genomics Research Institute, Flagstaff, Arizona, USA.
Krystal SheridanPathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.
Ashlyn PfeifferPathogen and Microbiome Division, Translational Genomics Research Institute, Flagstaff, Arizona, USA.
Hayley YaglomPathogen and Microbiome Division, Translational Genomics Research Institute, Flagstaff, Arizona, USA.
Darrin LemmerPathogen and Microbiome Division, Translational Genomics Research Institute, Flagstaff, Arizona, USA.
Jason W SahlPathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.
Emily A KaelinSchool of Life Sciences, Arizona State University, Tempe, Arizona, USA.
Rabia MaqsoodCenter for Fundamental and Applied Microbiomics, Biodesign Institute, Tempe, Arizona, USA.
Nicholas A BokulichPathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.
Grace QuirkDepartment of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, USA.
Thomas D WattsDepartment of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, USA.
Kenneth K KomatsuArizona Department of Health Services, Phoenix, Arizona, USA.
Victor WaddellBureau of Laboratory Services, Arizona Department of Health Services, Phoenix, Arizona, USA.
Efrem S LimSchool of Life Sciences, Arizona State University, Tempe, Arizona, USA.ORCID 0000-0002-3397-9310
J Gregory CaporasoCenter for Applied Microbiome Science, Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.ORCID 0000-0002-8865-1670
David M Engelthaler *Pathogen and Microbiome Division, Translational Genomics Research Institute, Flagstaff, Arizona, USA dengelthaler@tgen.org Worobey@arizona.edu Paul.Keim@nau.edu.ORCID 0000-0001-5945-059X
Michael Worobey *Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, USA dengelthaler@tgen.org Worobey@arizona.edu Paul.Keim@nau.edu.
Paul Keim *Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA dengelthaler@tgen.org Worobey@arizona.edu Paul.Keim@nau.edu.ORCID 0000-0003-0089-5820

Funding

The Virome and Microbiome in Health and BK Disease of Kidney Transplant PatientsR00DK107923 · NIDDK · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI LIM, EFREM · 2017 to 2019
$747k
NIDDK NIH HHS R00 DK107923
6 · The paper itself

Abstract

In December of 2019, a novel coronavirus, SARS-CoV-2, emerged in the city of Wuhan, China, causing severe morbidity and mortality. Since then, the virus has swept across the globe, causing millions of confirmed infections and hundreds of thousands of deaths. To better understand the nature of the pandemic and the introduction and spread of the virus in Arizona, we sequenced viral genomes from clinical samples tested at the TGen North Clinical Laboratory, the Arizona Department of Health Services, and those collected as part of community surveillance projects at Arizona State University and the University of Arizona. Phylogenetic analysis of 84 genomes from across Arizona revealed a minimum of 11 distinct introductions inferred to have occurred during February and March. We show that >80% of our sequences descend from strains that were initially circulating widely in Europe but have since dominated the outbreak in the United States. In addition, we show that the first reported case of community transmission in Arizona descended from the Washington state outbreak that was discovered in late February. Notably, none of the observed transmission clusters are epidemiologically linked to the original travel-related case in the state, suggesting successful early isolation and quarantine. Finally, we use molecular clock analyses to demonstrate a lack of identifiable, widespread cryptic transmission in Arizona prior to the middle of February 2020.

Indexed as

ArizonaBetacoronavirusCoronavirus InfectionsCOVID-19Evolution, MolecularGenome, ViralHumansIncidenceMutationPandemicsPhylogenyPneumonia, ViralSARS-CoV-2Viral ProteinsViral ProteinsArizonaCOVID-19genome analysismolecular clockphylogenetic analysis

Identifiers

PMID32887735
PMCPMC7474171

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.