Evidence map›Paper›PMID 32887711›Full record

ArticleDiabetes care2020

Medicaid Expansion and Utilization of Antihyperglycemic Therapies.

Andrew Sumarsono, Leo F Buckley, Sara R Machado, Rishi K Wadhera, Haider J Warraich, Rishi J Desai, Brendan M Everett, Darren K McGuire, Gregg C Fonarow, Javed Butler and 2 more

Abstract read
In one paragraph

Article in Diabetes care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Medicaid Expansion and Optimal Starts of Treatment for Incident Kidney Failure.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andrew SumarsonoDepartment of Internal Medicine, University of Texas Southwestern Medical Center, and Division of Hospital Medicine, Parkland Memorial Hospital, Dallas, TX.ORCID 0000-0002-5326-083X
Leo F BuckleyDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Sara R MachadoLondon School of Economics and Political Science, London, U.K.
Rishi K WadheraRichard A. and Susan F. Smith Center for Outcomes Research in Cardiology, Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
Haider J WarraichDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Rishi J DesaiDivision of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Brendan M EverettDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Darren K McGuireDivision of Cardiology, University of Texas Southwestern Medical Center and Parkland Health and Hospital System, Dallas, TX.ORCID 0000-0002-6412-7989
Gregg C FonarowAhmanson-UCLA Cardiomyopathy Center, University of California, Los Angeles, Los Angeles, CA.
Javed ButlerDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS.
Ambarish PandeyDivision of Cardiology, University of Texas Southwestern Medical Center and Parkland Health and Hospital System, Dallas, TX.ORCID 0000-0001-9651-3836
Muthiah VaduganathanDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA mvaduganathan@bwh.harvard.edu.ORCID 0000-0003-0885-1953

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
Inflammasome Activity as a Potential Contributor to Uremic CardiomyopathyK23HL150311 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BUCKLEY, LEO FRANCIS · 2020 to 2024
$1.1M
Explaining Rising Heart Failure Mortality in MedicareK23HL148525 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WADHERA, RISHI KUMAR · 2019 to 2023
$863k
NHLBI NIH HHS K23 HL148525
6 · The paper itself

Abstract

objectiveCertain antihyperglycemic therapies modify cardiovascular and kidney outcomes among patients with type 2 diabetes, but early uptake in practice appears restricted to particular demographics. We examine the association of Medicaid expansion with use of and expenditures related to antihyperglycemic therapies among Medicaid beneficiaries. RESEARCH DESIGN AND

methodsWe employed a difference-in-difference design to analyze the association of Medicaid expansion on prescription of noninsulin antihyperglycemic therapies. We used 2012-2017 national and state Medicaid data to compare prescription claims and costs between states that did (

resultsFollowing Medicaid expansion in 2014, average noninsulin antihyperglycemic therapies per state/1,000 enrollees increased by 4.2%/quarter in expansion states and 1.6%/quarter in nonexpansion states. For sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide 1 receptor agonists (GLP-1RA), quarterly growth rates per 1,000 enrollees were 125.3% and 20.7% for expansion states and 87.6% and 16.0% for nonexpansion states, respectively. Expansion states had faster utilization of SGLT2i and GLP-1RA than nonexpansion states. Difference-in-difference estimates for change in volume of prescriptions after Medicaid expansion between expansion versus nonexpansion states was 1.68 (95% CI 1.09-2.26;

conclusionsUse of noninsulin antihyperglycemic therapies, including SGLT2i and GLP-1RA, increased among low-income adults in both Medicaid expansion and nonexpansion states, with a significantly greater increase in overall use and in GLP-1RA use in expansion states. Future evaluation of the population-level health impact of expanded access to these therapies is needed.

Indexed as

Glucagon-Like Peptide-1 Receptor AgonistsAdultDiabetes Mellitus, Type 2Drug UtilizationFemaleGlucagon-Like Peptide-1 ReceptorHumansMaleMedicaidPatient Protection and Affordable Care ActPovertySodium-Glucose Transporter 2 InhibitorsUnited StatesGLP1R protein, humanGlucagon-Like Peptide-1 ReceptorGlucagon-Like Peptide-1 Receptor AgonistsSodium-Glucose Transporter 2 Inhibitors

Identifiers

PMID32887711
PMCPMC8051258

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.