ArticleeNeuro
Activation of Subthalamic Nucleus Stop Circuit Disrupts Cognitive Performance.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Effects of chronic stress on cognitive function - From neurobiology to intervention.Neurobiology of stress · 2024Review
- Memory, mood and associated neuroanatomy in individuals with steroid sulphatase deficiency (X-linked ichthyosis).Genes, brain, and behavior · 2024Article
- Architecture of the subthalamic nucleus.Communications biology · 2024Review
- Selective Activation of Subthalamic Nucleus Output Quantitatively Scales Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Optogenetics in Alzheimer's Disease: Focus on Astrocytes.Antioxidants (Basel, Switzerland) · 2023Review
- High precision magnetoencephalography reveals increased right-inferior frontal gyrus beta power during response conflict.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- Dynamic control of visually guided locomotion through corticosubthalamic projections.Cell reports · 2022Article
- Optogenetics: implications for Alzheimer's disease research and therapy.Molecular brain · 2022Review
- Bidirectional Optogenetic Modulation of the Subthalamic Nucleus in a Rodent Model of Parkinson's Disease.Frontiers in neuroscience · 2022Article
- Article
- Towards real-world generalizability of a circuit for action-stopping.Nature reviews. Neuroscience · 2021Review
- The "when" and "where" of the interplay between attentional capture and response inhibition during a Go/NoGo variant.NeuroImage · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Much evidence supports a fundamental role for the subthalamic nucleus (STN) in rapidly stopping behavior when a stop signal or surprising event occurs, but the extent to which the STN may be involved in stopping cognitive processes is less clear. Here, we used an optogenetic approach to control STN activity in a delayed-match-to-position (DMTP) task where mice had to recall a response location after a delay. We first demonstrated that a surprising event impaired performance by both slowing the latency to respond and increasing the rate of errors. We next showed that these effects could be mimicked by brief optogenetic activation of the STN. Further, inhibiting STN during surprise blocked surprise-induced slowing, although without changing surprise-induced errors. These data are consistent with the hypothesis that STN is recruited by surprise to slow responding and that this can also interrupt cognitive processes. Under normal conditions STN-mediated stopping of behavior may slow or stop ongoing cognition to facilitate cognitive reorienting and adaptive responses to unexpected sensory information, but when malfunctioning, it could produce pathologies related to over-rigidity or increased distractibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.