Evidence map›Paper›PMID 32887692›Full record

ArticleeNeuro

TGFβ1 Induces Axonal Outgrowth via ALK5/PKA/SMURF1-Mediated Degradation of RhoA and Stabilization of PAR6.

Julia Kaiser, Martina Maibach, Ester Piovesana, Iris Salpeter, Nora Escher, Yannick Ormen, Martin E Schwab

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Adamts10 controls transforming growth factorFrontiers in molecular biosciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Julia KaiserBrain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland juk4004@med.cornell.edu.ORCID 0000-0001-5142-6050
Martina MaibachBrain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland.
Ester PiovesanaBrain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland.
Iris SalpeterBrain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland.
Nora EscherBrain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland.
Yannick OrmenBrain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland.
Martin E SchwabBrain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland.
University of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transforming growth factor (TGF)β1 has repeatedly been associated with axonal regeneration and recovery after injury to the CNS. We found TGFβ1 upregulated in the stroke-denervated mouse spinal cord after ischemic injury to the motor cortex as early as 4 d postinjury (dpi) and persisting up to 28 dpi. Given the potential role of TGFβ1 in structural plasticity and functional recovery after stroke highlighted in several published studies, we investigated its downstream signaling in an

Indexed as

Cyclic AMP-Dependent Protein KinasesNeuronal OutgrowthTransforming Growth Factor beta1Adaptor Proteins, Signal TransducingAnimalsHumansMicePhosphorylationReceptor, Transforming Growth Factor-beta Type IRecovery of FunctionrhoA GTP-Binding ProteinSignal TransductionUbiquitin-Protein LigasesAdaptor Proteins, Signal TransducingCyclic AMP-Dependent Protein KinasesPARD6A protein, humanReceptor, Transforming Growth Factor-beta Type IrhoA GTP-Binding ProteinRHOA protein, humanSMURF1 protein, humanTGFB1 protein, humanTGFBR1 protein, humanTransforming Growth Factor beta1Ubiquitin-Protein Ligasesdownstream signalingneurite outgrowthplasticitystroketgfb1

Identifiers

PMID32887692
PMCPMC7540929
OpenAlexW3083160932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.