Evidence map›Paper›PMID 32887656›Full record

ArticleBreast cancer research : BCR2020

Aspirin use and risk of breast cancer in African American women.

Kimberly A Bertrand, Traci N Bethea, Hanna Gerlovin, Patricia F Coogan, Lauren Barber, Lynn Rosenberg, Julie R Palmer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research : BCR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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  3. Article
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  6. Potential of Anti-inflammatory Molecules in the Chemoprevention of Breast Cancer.Recent advances in inflammation & allergy drug discovery · 2022
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kimberly A BertrandSlone Epidemiology Center at Boston University, 72 East Concord Street, L-7, Boston, MA, 02118, USA. kab15@bu.edu.ORCID 0000-0002-4565-7618
Traci N BetheaSlone Epidemiology Center at Boston University, 72 East Concord Street, L-7, Boston, MA, 02118, USA.
Hanna GerlovinSlone Epidemiology Center at Boston University, 72 East Concord Street, L-7, Boston, MA, 02118, USA.
Patricia F CooganSlone Epidemiology Center at Boston University, 72 East Concord Street, L-7, Boston, MA, 02118, USA.
Lauren BarberDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Lynn RosenbergSlone Epidemiology Center at Boston University, 72 East Concord Street, L-7, Boston, MA, 02118, USA.
Julie R PalmerSlone Epidemiology Center at Boston University, 72 East Concord Street, L-7, Boston, MA, 02118, USA.
Boston University · US

Funding

A Follow-up Study for Causes of Cancer in Black WomenU01CA164974 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Kimberly A. Bertrand, Yvette C Cozier · 2017 to 2026
$24.0M
FOLLOW-UP STUDY FOR CAUSES OF ILLNESS IN BLACK WOMENR01CA058420 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENBERG, LYNN · 1999 to 2013
$20.7M
A Follow-up Study for Causes of Cancer in Black WomenUM1CA164974 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENBERG, LYNN · 2012 to 2017
$13.7M
An assessment of whether aspirin and/or vitamin D improves breast cancer outcomes in Black women and the modifying effect of genetic variantsK01CA212056 · NCI · GEORGETOWN UNIVERSITY · PI BETHEA, TRACI N. · 2017 to 2021
$656k
FOLLOW-UP STUDY FOR CAUSES OF ILLNESS IN BLACK WOMENU01CA058420 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENBERG, LYNN · 1994 to 1998
–
NCI NIH HHS CA058420NCI NIH HHS K01 CA212056NCI NIH HHS U01 CA164974NCI NIH HHS UM1 CA164974
6 · The paper itself

Abstract

backgroundUse of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been hypothesized to be associated with reduced risk of breast cancer; however, results of epidemiological studies have been mixed. Few studies have investigated these associations among African American women.

methodsTo assess the relation of aspirin use to risk of breast cancer in African American women, we conducted a prospective analysis within the Black Women's Health Study, an ongoing nationwide cohort study of 59,000 African American women. On baseline and follow-up questionnaires, women reported regular use of aspirin (defined as use at least 3 days per week) and years of use. During follow-up from 1995 through 2017, 1919 invasive breast cancers occurred, including 1112 ER+, 569 ER-, and 284 triple-negative (TN) tumors. We used age-stratified Cox proportional hazards regression models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations of aspirin use with risk of ER+, ER-, and TN breast cancer, adjusted for established breast cancer risk factors.

resultsOverall, the HR for current regular use of aspirin relative to non-use was 0.92 (95% CI 0.81, 1.04). For ER+, ER-, and TN breast cancer, corresponding HRs were 0.98 (0.84, 1.15), 0.81 (0.64, 1.04), and 0.70 (0.49, 0.99), respectively.

conclusionsOur findings with regard to ER- and TN breast cancer are consistent with hypothesized inflammatory mechanisms of ER- and TN breast cancer, rather than hormone-dependent pathways. Aspirin may represent a potential opportunity for chemoprevention of ER- and TN breast cancer.

Indexed as

AdultAgedAnti-Inflammatory Agents, Non-SteroidalAspirinBlack or African AmericanBreast NeoplasmsErb-b2 Receptor Tyrosine KinasesFemaleHumansIncidenceMiddle AgedProportional Hazards ModelsProspective StudiesReceptors, EstrogenReceptors, ProgesteroneRisk FactorsAnti-Inflammatory Agents, Non-SteroidalAspirinERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesReceptors, EstrogenReceptors, ProgesteroneAfrican AmericanAspirinBreast cancerNon-steroidal anti-inflammatory drugsRisk

Identifiers

PMID32887656
PMCPMC7650295
OpenAlexW3083660198

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.