ArticleBMC musculoskeletal disorders2020
The acromioclavicular ligament shows an early and dynamic healing response following acute traumatic rupture.
Article in BMC musculoskeletal disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 22 citations in OpenAlex.
- Surgical Timing After Acromioclavicular Joint Separation: Association With Clinical Outcomes.Orthopaedic journal of sports medicine · 2026Article
- [Dislocation of the acromioclavicular joint].Orthopadie (Heidelberg, Germany) · 2026Review
- Anatomical reconstruction of coracoclavicular and acromioclavicular ligaments using an autologous tendon graft provides excellent outcomes in acute acromioclavicular joint dislocation.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- Proximal humerus fracture and acromioclavicular joint dislocation.Innovative surgical sciences · 2024Review
- Current trends in surgical treatment of the acromioclavicular joint injuries in 2023: a review of the literature.JSES international · 2024Review
- Ligament injury in adult zebrafish triggers ECM remodeling and cell dedifferentiation for scar-free regeneration.NPJ Regenerative medicine · 2023Article
- Ligament injury in adult zebrafish triggers ECM remodeling and cell dedifferentiation for scar-free regeneration.bioRxiv : the preprint server for biology · 2023Article
- Current concepts in acromioclavicular joint (AC) instability - a proposed treatment algorithm for acute and chronic AC-joint surgery.BMC musculoskeletal disorders · 2022Review
- Ligamentous healing potential of the acromioclavicular ligament following acute anatomical reconstruction.Archives of orthopaedic and trauma surgery · 2022Article
- Arthroscopic-Assisted Coracoclavicular Stabilization With Anchorless Transosseous Double-Row Acromioclavicular Ligament Complex Repair: The Acute Acromioclavicular Joint Dislocation.Arthroscopy techniques · 2022Article
- The Morphology of the Acromioclavicular Joint Does Not Influence the Postoperative Outcome Following Acute Stabilization-A Case Series of 81 Patients.Arthroscopy, sports medicine, and rehabilitation · 2022Article
- Arthroscopic Anatomical Acromioclavicular Joint Reconstruction using a Button Device and a Semitendinosus Graft.Orthopaedic surgery · 2022Article
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Authors and funding
9 authors at 3 institutions in 1 country.
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Abstract
purposeSymptomatic horizontal instability is clinically relevant following acute acromioclavicular joint dislocations. However, the intrinsic healing response is poorly understood. The present study sought to investigate time-dependent healing responses of the human acromioclavicular ligament following acute traumatic rupture.
methodsBiopsies of the acromioclavicular ligament were obtained from patients undergoing surgical treatment for acute acromioclavicular joint dislocations. Specimens were stratified by time between trauma and surgery: group 1, 0-7 days (n = 5); group 2, 8-14 days (n = 6); and group 3, 15-21 days (n = 4). Time-dependent changes in cellularity, collagen (type 1 and 3) concentration, and histomorphological appearance were evaluated for the rupture and intact zone of the acromioclavicular ligament.
resultsGroup 1 was characterized by cellular activation and early inflammatory response. The rupture zone exhibited a significantly higher count of CD68-positive cells than the intact zone (15.2 vs 7.4; P ≤ 0.05). Consistently, synovialization of the rupture end was observed. Within the second week, the rupture zone was subject to proliferation showing more fibroblast-like cells than the intact zone (66.8 vs 43.8; P ≤ 0.05) and a peak of collagen type 3 expression (group 1: 2.2 ± 0.38, group 2: 3.2 ± 0.18, group 3: 2.8 ± 0.57; P ≤ 0.05). Signs of consolidation and early remodeling were seen in the third week.
conclusionsThe acromioclavicular ligament exhibits early and dynamic healing responses following acute traumatic rupture. Our histological findings suggest that surgical treatment of acute ACJ dislocations should be performed as early as possible within a timeframe of 1 week after trauma to exploit the utmost biological healing potential. Prospective clinical studies are warranted to investigate whether early surgical treatment of ACJ dislocations translates into clinical benefits.
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