Evidence map›Paper›PMID 32887507›Full record

ArticleToxins2020

Mechanisms of Tolerance and Resistance to Chlorhexidine in Clinical Strains of

Ines Bleriot, Lucia Blasco, Mercedes Delgado-Valverde, Ana Gual-de-Torrella, Anton Ambroa, Laura Fernandez-Garcia, Maria Lopez, Jesus Oteo-Iglesias, Thomas K Wood, Alvaro Pascual and 3 more

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

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  3. Lactobacillus acidophilus VB1 co-aggregates and inhibits biofilm formation of chronic otitis media-associated pathogens.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Ines BleriotMicrobiology Department-Research Institute Biomedical A Coruña (INIBIC), Hospital A Coruña (CHUAC), University of A Coruña (UDC), 15006 A Coruña, Spain.ORCID 0000-0002-1846-4693
Lucia BlascoMicrobiology Department-Research Institute Biomedical A Coruña (INIBIC), Hospital A Coruña (CHUAC), University of A Coruña (UDC), 15006 A Coruña, Spain.ORCID 0000-0002-4039-4142
Mercedes Delgado-ValverdeClinical Unit for Infectious Diseases, Department of Microbiology and Medicine, Microbiology and Preventive Medicine, Hospital Universitario Virgen Macarena, University of Seville, Biomedicine Insititute of Seville (IBIS), 41009 Seville, Spain.ORCID 0000-0002-2961-2620
Ana Gual-de-TorrellaClinical Unit for Infectious Diseases, Department of Microbiology and Medicine, Microbiology and Preventive Medicine, Hospital Universitario Virgen Macarena, University of Seville, Biomedicine Insititute of Seville (IBIS), 41009 Seville, Spain.ORCID 0000-0003-0470-418X
Anton AmbroaMicrobiology Department-Research Institute Biomedical A Coruña (INIBIC), Hospital A Coruña (CHUAC), University of A Coruña (UDC), 15006 A Coruña, Spain.
Laura Fernandez-GarciaMicrobiology Department-Research Institute Biomedical A Coruña (INIBIC), Hospital A Coruña (CHUAC), University of A Coruña (UDC), 15006 A Coruña, Spain.ORCID 0000-0002-8531-6105
Maria LopezMicrobiology Department-Research Institute Biomedical A Coruña (INIBIC), Hospital A Coruña (CHUAC), University of A Coruña (UDC), 15006 A Coruña, Spain.
Jesus Oteo-IglesiasStudy Group on Mechanisms of Action and Resistance to Antimicrobials (GEMARA) the Behalf of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), 28003 Madrid, Spain.ORCID 0000-0003-3327-8263
Thomas K WoodDepartment of Chemical Engineering, Pennsylvania State University, University Park, PA 16801, USA.ORCID 0000-0002-6258-529X
Alvaro PascualStudy Group on Mechanisms of Action and Resistance to Antimicrobials (GEMARA) the Behalf of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), 28003 Madrid, Spain.
German BouMicrobiology Department-Research Institute Biomedical A Coruña (INIBIC), Hospital A Coruña (CHUAC), University of A Coruña (UDC), 15006 A Coruña, Spain.
Felipe Fernandez-CuencaStudy Group on Mechanisms of Action and Resistance to Antimicrobials (GEMARA) the Behalf of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), 28003 Madrid, Spain.
Maria TomasMicrobiology Department-Research Institute Biomedical A Coruña (INIBIC), Hospital A Coruña (CHUAC), University of A Coruña (UDC), 15006 A Coruña, Spain.ORCID 0000-0003-4501-0387
Universidade da Coruña · ESHospital Universitario Virgen Macarena · ESInstituto de Salud Carlos III · ESPennsylvania State University · US

Funding

Instituto de Salud Carlos III PI16/01163Instituto de Salud Carlos III PI19/00878
6 · The paper itself

Abstract

Although the failure of antibiotic treatment is normally attributed to resistance, tolerance and persistence display a significant role in the lack of response to antibiotics. Due to the fact that several nosocomial pathogens show a high level of tolerance and/or resistance to chlorhexidine, in this study we analyzed the molecular mechanisms associated with chlorhexidine adaptation in two clinical strains of

Indexed as

Anti-Infective Agents, LocalBacterial Proteinsbeta-LactamasesChlorhexidineDrug Resistance, BacterialImipenemKlebsiella pneumoniaeToxin-Antitoxin SystemsDrug CombinationsTime FactorsAnti-Infective Agents, LocalBacterial Proteinsbeta-LactamasescarbapenemaseChlorhexidineDrug CombinationsImipenemcross-resistanceKlebsiella pneumoniaePemI/PemKpersistencetolerancetoxin-antitoxin system

Identifiers

PMID32887507
PMCPMC7551900
OpenAlexW3081610036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.