Evidence map›Paper›PMID 32887488›Full record

ArticleViruses2020

The Phage-Encoded

Pieter-Jan Ceyssens, Jeroen De Smet, Jeroen Wagemans, Natalia Akulenko, Evgeny Klimuk, Subray Hedge, Marleen Voet, Hanne Hendrix, Jan Paeshuyse, Bart Landuyt and 4 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. The biology of jumbo phages.Nature communications · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Genome and Ecology of a NovelMicrobiology spectrum · 2021
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Pieter-Jan CeyssensDepartment of Biosystems, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0001-7735-8316
Jeroen De SmetDepartment of Biosystems, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-7200-089X
Jeroen WagemansDepartment of Biosystems, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-2185-5724
Natalia AkulenkoInstitute of Molecular Genetics, Russian Academy of Sciences, 119334 Moscow, Russia.
Evgeny KlimukInstitute of Molecular Genetics, Russian Academy of Sciences, 119334 Moscow, Russia.ORCID 0000-0001-5314-038X
Subray HedgeDepartment of Biochemistry, Albert Einstein College of Medicine, New York, NY 10461, USA.
Marleen VoetDepartment of Biosystems, KU Leuven, 3000 Leuven, Belgium.
Hanne HendrixDepartment of Biosystems, KU Leuven, 3000 Leuven, Belgium.
Jan PaeshuyseDepartment of Biosystems, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0003-2396-354X
Bart LanduytDepartment of Biology, KU Leuven, 3000 Leuven, Belgium.
Hua XuDepartment of Biochemistry, Albert Einstein College of Medicine, New York, NY 10461, USA.
John BlanchardDepartment of Biochemistry, Albert Einstein College of Medicine, New York, NY 10461, USA.
Konstantin SeverinovInstitute of Molecular Genetics, Russian Academy of Sciences, 119334 Moscow, Russia.
Rob LavigneDepartment of Biosystems, KU Leuven, 3000 Leuven, Belgium.
KU Leuven · BEAlbert Einstein College of Medicine · USInstitute of Molecular Genetics · RU

Funding

2D-DIGE SYSTEM FOR PROTEOMICS: SIGNAL TRANSDUCT &CELL COMMUNICAT, &CELL BIOLS10RR021056 · NCRR · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI ANGELETTI, RUTH HOGUE · 2005 to 2005
$180k
NCRR NIH HHS S10 RR021056
6 · The paper itself

Abstract

In this study, we describe the biological function of the phage-encoded protein RNA polymerase alpha subunit cleavage protein (Rac), a predicted Gcn5-related acetyltransferase encoded by phiKMV-like viruses. These phages encode a single-subunit RNA polymerase for transcription of their late (structure- and lysis-associated) genes, whereas the bacterial RNA polymerase is used at the earlier stages of infection. Rac mediates the inactivation of bacterial transcription by introducing a specific cleavage in the α subunit of the bacterial RNA polymerase. This cleavage occurs within the flexible linker sequence and disconnects the C-terminal domain, required for transcription initiation from most highly active cellular promoters. To achieve this, Rac likely taps into a novel post-translational modification (PTM) mechanism within the host

Indexed as

AcetyltransferasesBacterial ProteinsDNA-Directed RNA PolymerasesHost-Pathogen InteractionsPseudomonas aeruginosaPseudomonas PhagesTranscription, GeneticViral ProteinsAcetyltransferasesBacterial ProteinsDNA-Directed RNA PolymerasesRNA polymerase alpha subunitViral Proteinshost transcriptional shutdownphage–host interactionsphage-induced acetylation

Identifiers

PMID32887488
PMCPMC7552054
OpenAlexW3081551093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.