Evidence map›Paper›PMID 32887302›Full record

ArticleVaccines2020

A Zika Vaccine Generated Using the Chimeric Insect-Specific Binjari Virus Platform Protects against Fetal Brain Infection in Pregnant Mice.

Jessamine E Hazlewood, Daniel J Rawle, Bing Tang, Kexin Yan, Laura J Vet, Eri Nakayama, Jody Hobson-Peters, Roy A Hall, Andreas Suhrbier

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Evolution of Zika virus inVirus evolution · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jessamine E HazlewoodInflammation Biology Group, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.ORCID 0000-0001-6104-4531
Daniel J RawleInflammation Biology Group, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.ORCID 0000-0001-7248-0101
Bing TangInflammation Biology Group, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Kexin YanInflammation Biology Group, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Laura J VetSchool of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0001-7587-2936
Eri NakayamaDepartment of Virology I, National Institute of Infectious Diseases, Tokyo 162-0052, Japan.ORCID 0000-0002-0826-3513
Jody Hobson-PetersSchool of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0003-0139-9829
Roy A HallSchool of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, QLD 4072, Australia.
Andreas SuhrbierInflammation Biology Group, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.ORCID 0000-0001-8986-9025
QIMR Berghofer Medical Research Institute · AUThe University of Queensland · AUNational Institute of Infectious Diseases · JP

Funding

National Health and Medical Research Council APP1173880National Health and Medical Research Council APP1178896
6 · The paper itself

Abstract

Zika virus (ZIKV) is the etiological agent of congenital Zika syndrome (CZS), a spectrum of birth defects that can lead to life-long disabilities. A range of vaccines are in development with the target population including pregnant women and women of child-bearing age. Using a recently described chimeric flavivirus vaccine technology based on the novel insect-specific Binjari virus (BinJV), we generated a ZIKV vaccine (BinJ/ZIKA-prME) and illustrate herein its ability to protect against fetal brain infection. Female IFNAR

Indexed as

Binjaridenguemouse modelvaccineZika

Identifiers

PMID32887302
PMCPMC7564101
OpenAlexW3082268888

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.