Evidence map›Paper›PMID 32887284›Full record

ArticleViruses2020

Inter-Laboratory Reproducibility of Inducible HIV-1 Reservoir Quantification by TILDA.

Cynthia Lungu, Francesco A Procopio, Ronald J Overmars, Rob J J Beerkens, Jolanda J C Voermans, Shringar Rao, Henrieke A B Prins, Casper Rokx, Giuseppe Pantaleo, David A M C van de Vijver and 4 more

Abstract readValidation Study
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. The reservoir of latent HIV.Frontiers in cellular and infection microbiology · 2022
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Cynthia LunguDepartment of Viroscience, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
Francesco A ProcopioService of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Ronald J OvermarsDepartment of Viroscience, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
Rob J J BeerkensDepartment of Viroscience, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
Jolanda J C VoermansDepartment of Viroscience, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
Shringar RaoDepartment of Biochemistry, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0003-2242-7331
Henrieke A B PrinsDepartment of Internal Medicine, Section of Infectious Diseases, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
Casper RokxDepartment of Internal Medicine, Section of Infectious Diseases, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
Giuseppe PantaleoService of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
David A M C van de VijverDepartment of Viroscience, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
Tokameh MahmoudiDepartment of Biochemistry, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
Charles A B BoucherDepartment of Viroscience, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
Rob A GrutersDepartment of Viroscience, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-8486-5903
Jeroen J A van KampenDepartment of Viroscience, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Substantial efforts to eliminate or reduce latent HIV-1 reservoirs are underway in clinical trials and have created a critical demand for sensitive, accurate, and reproducible tools to evaluate the efficacy of these strategies. Alternative reservoir quantification assays have been developed to circumvent limitations of the quantitative viral outgrowth assay. One such assay is

Indexed as

AdultCD4-Positive T-LymphocytesFemaleHIV-1HIV InfectionsHumansLaboratoriesMaleMiddle AgedProvirusesReproducibility of ResultsVirologyVirus LatencyYoung Adultassay performanceHIV-1 latencyinducible reservoirsreservoir quantificationTILDA

Identifiers

PMID32887284
PMCPMC7552071

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.