Evidence map›Paper›PMID 32887218›Full record

ArticleMolecules (Basel, Switzerland)2020

In Silico Analyses and Cytotoxicity Study of Asiaticoside and Asiatic Acid from Malaysian Plant as Potential mTOR Inhibitors.

Ninie Nadia Zulkipli, Rahimah Zakaria, Idris Long, Siti Fadilah Abdullah, Erma Fatiha Muhammad, Habibah A Wahab, Teguh Haryo Sasongko

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Can Asiatic Acid fromCancers · 2024
    Review
  3. [Effect of asiaticoside on systolic blood pressure and relaxation of isolated thoracic aorta of rats].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ninie Nadia ZulkipliSchool of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Malaysia.
Rahimah ZakariaSchool of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Malaysia.ORCID 0000-0002-2459-3213
Idris LongSchool of Health Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Malaysia.ORCID 0000-0002-6828-1908
Siti Fadilah AbdullahSchool of Dental Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Malaysia.
Erma Fatiha MuhammadSchool of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang 11800, Malaysia.
Habibah A WahabSchool of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang 11800, Malaysia.
Teguh Haryo SasongkoSchool of Medicine, Perdana University-RCSI, Jalan MAEPS Perdana, Serdang 43400, Malaysia.
Universiti Sains Malaysia · MYPerdana University · MY

Funding

Universiti Sains Malaysia Research University Grant 1001/PPSP/812137 and 1001/PFarmasi/ 870031
6 · The paper itself

Abstract

Natural products remain a popular alternative treatment for many ailments in various countries. This study aimed to screen for potential mammalian target of rapamycin (mTOR) inhibitors from Malaysian natural substance, using the Natural Product Discovery database, and to determine the IC

Indexed as

Computer SimulationCell DeathCell Line, TumorEverolimusHumansHydrogen BondingHydrophobic and Hydrophilic InteractionsMalaysiaMolecular Docking SimulationPentacyclic TriterpenesPlantsProtein Kinase InhibitorsTOR Serine-Threonine KinasesTriterpenesasiatic acidasiaticosideEverolimusPentacyclic TriterpenesProtein Kinase InhibitorsTOR Serine-Threonine KinasesTriterpenesasiatic acidasiaticosideeverolimusIC50mammalian target of rapamycin (mTOR)molecular docking

Identifiers

PMID32887218
PMCPMC7504803
OpenAlexW3082872877

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.