Evidence map›Paper›PMID 32887217›Full record

ArticleInternational journal of molecular sciences2020

Arctigenin Attenuates Breast Cancer Progression through Decreasing GM-CSF/TSLP/STAT3/β-Catenin Signaling.

Hui Shi, Luping Zhao, Xinlin Guo, Runping Fang, Hui Zhang, Guanjun Dong, Jia Fu, Fenglian Yan, Junfeng Zhang, Zhaochen Ning and 6 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Arctigenin fromNutrients · 2025
    Article
  5. Review
  6. Arctigenin Suppresses MelanomaCurrent cancer drug targets · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Phytochemicals Target Multiple Metabolic Pathways in Cancer.Antioxidants (Basel, Switzerland) · 2023
    Review
  11. Review
  12. Targeting PI3K/Akt signaling in prostate cancer therapy.Journal of cell communication and signaling · 2023
    Review
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Hui ShiInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining 272067, China.
Luping ZhaoInstitute of Basic Medical College, Jining Medical University, Jining 272067, China.
Xinlin GuoInstitute of Basic Medical College, Jining Medical University, Jining 272067, China.
Runping FangState Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, China.
Hui ZhangInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining 272067, China.
Guanjun DongInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining 272067, China.
Jia FuInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining 272067, China.
Fenglian YanInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining 272067, China.
Junfeng ZhangInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining 272067, China.
Zhaochen NingInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining 272067, China.
Qun MaInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining 272067, China.
Zhihua LiInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining 272067, China.
Chunxia LiInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining 272067, China.
Jun DaiInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining 272067, China.
Chuanping SiInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining 272067, China.
Huabao XiongInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining 272067, China.
Jining Medical University · CNNankai University · CN

Funding

National Natural Science Foundation of China 81802856National Natural Science Foundation of China 81874169Projects of Shandong Province Higher Education Science and Technology Program, China J17KA230Shandong University Students Innovation and Entrepreneurship Training Program 201910443011
6 · The paper itself

Abstract

Invasive breast cancer is highly regulated by tumor-derived cytokines in tumor microenvironment. The development of drugs that specifically target cytokines are promising in breast cancer treatment. In this study, we reported that arctigenin, a bioactive compound from

Indexed as

AnimalsApoptosisbeta CateninBiomarkers, TumorBreast NeoplasmsCell MovementCell ProliferationCytokinesFemaleFuransGene Expression Regulation, NeoplasticGranulocyte-Macrophage Colony-Stimulating FactorHumansLignansMiceMice, Inbred BALB Carctigeninbeta CateninBiomarkers, TumorCTNNB1 protein, humanCytokinesFuransGranulocyte-Macrophage Colony-Stimulating FactorLignansSTAT3 protein, humanSTAT3 Transcription FactorThymic Stromal LymphopoietinTSLP protein, humanArctigeninbreast cancerGM-CSFSTAT3TSLPβ-catenin

Identifiers

PMID32887217
PMCPMC7503539
OpenAlexW3082455880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.