Evidence map›Paper›PMID 32886885›Full record

ArticleACS infectious diseases2020

Evaluation of Bacterial RNA Polymerase Inhibitors in a

Jörg Haupenthal, Yannik Kautz, Walid A M Elgaher, Linda Pätzold, Teresa Röhrig, Matthias W Laschke, Thomas Tschernig, Anna K H Hirsch, Vadim Molodtsov, Katsuhiko S Murakami and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Jörg HaupenthalDepartment of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Saarland, Germany.ORCID 0000-0003-3991-2800
Yannik KautzInstitute of Medical Microbiology and Hygiene, Saarland University, 66421 Homburg, Saarland, Germany.
Walid A M ElgaherDepartment of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Saarland, Germany.ORCID 0000-0002-8766-4568
Linda PätzoldInstitute of Medical Microbiology and Hygiene, Saarland University, 66421 Homburg, Saarland, Germany.
Teresa RöhrigDepartment of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Saarland, Germany.
Matthias W LaschkeInstitute for Clinical & Experimental Surgery, Saarland University, 66421 Homburg, Saarland, Germany.
Thomas TschernigInstitute of Anatomy and Cell Biology, Saarland University, 66421 Homburg, Saarland, Germany.
Anna K H HirschDepartment of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Saarland, Germany.ORCID 0000-0001-8734-4663
Vadim MolodtsovDepartment of Biochemistry and Molecular Biology, The Center for RNA Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Katsuhiko S MurakamiDepartment of Biochemistry and Molecular Biology, The Center for RNA Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Rolf W HartmannDepartment of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Saarland, Germany.ORCID 0000-0002-5871-5231
Markus BischoffInstitute of Medical Microbiology and Hygiene, Saarland University, 66421 Homburg, Saarland, Germany.
Helmholtz Centre for Infection Research · DEInstitute of Medical Microbiology and Hygiene · DEPennsylvania State University · USSaarland University · DE

Funding

X-Ray Crystallographic Studies of Multi-Subunit Nucleic Acid PolymerasesR01GM087350 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI MURAKAMI, KATSUHIKO · 2010 to 2018
$2.6M
Structural study of direct associations between cellular RNA polymerase and regulatory factors during the transcription cycleR35GM131860 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI MURAKAMI, KATSUHIKO · 2019 to 2023
$2.2M
NIGMS NIH HHS R01 GM087350NIGMS NIH HHS R35 GM131860
6 · The paper itself

Abstract

Chronic wounds infected with pathogens such as

Indexed as

Staphylococcal InfectionsWound InfectionAnimalsAnti-Bacterial AgentsDNA-Directed RNA PolymerasesHumansMiceStaphylococcus aureusAnti-Bacterial AgentsDNA-Directed RNA Polymerasesanti-infectivesdrug developmentRNA polymerase inhibitorSKH1 miceStaphylococcus aureuswound infection model

Identifiers

PMID32886885
PMCPMC7956220
OpenAlexW3083316230

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.