ArticleAging cell2020
Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice.
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Article in Aging cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
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Who cites it
32 citing papers in PubMed, 58 citations in OpenAlex.
- Plasma CAF22 Predicts Incident Freezing of Gait in Parkinson's Disease: A Prospective Cohort Study.Journal of molecular neuroscience : MN · 2026Article
- Clarifying the molecular mechanisms underlying the lethal in vitro cellular effects and mild organismal phenotype of SOD1 loss.Scientific reports · 2026Article
- The food grade bacterium Lactobacillus helveticus VEL12193 promotes autophagy by releasing membrane vesicles.Cell communication and signaling : CCS · 2026Article
- Episodic denervation as a driver of loss of skeletal muscle redox homeostasis and muscle weakness in sarcopenia: Possible amelioration by exercise.Sports medicine and health science · 2025Review
- Associations of plasma Neurofilament light chain with sarcopenia and physical capacity in patients with Alzheimer's diseases.Acta neurologica Belgica · 2025Observational
- Skeletal muscle innervation: Reactive oxygen species as regulators of neuromuscular junction dynamics and motor unit remodeling.Free radical biology & medicine · 2025Review
- Reactive oxygen species in the pathogenesis of sarcopenia.Free radical biology & medicine · 2025Review
- Myotendinous junction: a microenvironment favorable for short-term adaptations to resistance training following gastrocnemius muscle atrophy.Frontiers in physiology · 2025Article
- The Interface of a Leaky Gut with Reduced Sarcopenia-Related Quality of Life (SarQoL) in Patients with Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2025Article
- Mouse models used to test the role of reactive oxygen species in aging and age-related chronic diseases.Free radical biology & medicine · 2024Review
- Neuroprotective treatment with the nitrone compound OKN-007 mitigates age-related muscle weakness in aging mice.GeroScience · 2024Article
- Tracking the Plasma C-Terminal Agrin Fragment as a Biomarker of Neuromuscular Decline in 18- to 87-Year-Old Men.Molecular diagnosis & therapy · 2024Article
- The Association of Intestinal Leak with Sarcopenia and Physical Disability in Patients with Various Stages of Chronic Kidney Disease.Calcified tissue international · 2024Article
- Senolytic treatment does not mitigate oxidative stress-induced muscle atrophy but improves muscle force generation in CuZn superoxide dismutase knockout mice.GeroScience · 2024Article
- Lipid-Lowering Medications are Associated with Reduced Sarcopenia-Related Quality of Life in Older Adults with Hyperlipidemia.Drugs & aging · 2024Article
- The Pathology of Intestinal Mucosal Disruption; Implications for Muscle Loss and Physical Dependency from Late Adolescence to Octogenarians.International journal of general medicine · 2024Article
- Article
- Older mice show decreased regeneration of neuromuscular junctions following lengthening contraction-induced injury.GeroScience · 2023Article
- Deletion ofeNeuro · 2023Article
- Elevated plasma CAF22 are incompletely restored six months after COVID-19 infection in older men.Experimental gerontology · 2023Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Shylesh BhaskaranAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Natalie PollockDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA), University of Liverpool, Liverpool, UK.
Peter C MacphersonDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Bumsoo AhnAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Katarzyna M PiekarzAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.ORCID 0000-0003-4710-9970
Caroline A StauntonDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA), University of Liverpool, Liverpool, UK.
Jacob L BrownAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Rizwan QaisarAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Aphrodite VasilakiDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA), University of Liverpool, Liverpool, UK.
Arlan RichardsonOklahoma City VA Medical Center, Oklahoma City, OK, USA.
Anne McArdleDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA), University of Liverpool, Liverpool, UK.
Malcolm J JacksonDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA), University of Liverpool, Liverpool, UK.
Susan V BrooksDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Holly Van RemmenAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.ORCID 0000-0003-0883-0642
Oklahoma Medical Research Foundation · USUniversity of Liverpool · GBUniversity of Michigan · USOklahoma City VA Medical Center · US
Funding
PROJECT 3: Neuromuscular redox homeostasis in mice lacking SOD1 and aging wild type mice subcontract at University of LiverpoolP01AG051442 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JACKSON, MALCOLM JOSEPH · 2016 to 2020
$8.9MDefining the relative roles of pre- and post-synaptic events in the initiation and progression of sarcopeniaR01AG050676 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROOKS, SUSAN V, VAN REMMEN, HOLLY · 2016 to 2020
$3.3MThe role of unacylated ghrelin on age-associated progressive muscle weakness and cachexia elicited by cancerR00AG064143 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI AHN, BUMSOO · 2022 to 2024
$839kThe role of unacylated ghrelin on age-associated progressive muscle weakness and cachexia elicited by cancerK99AG064143 · NIA · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI AHN, BUMSOO · 2020 to 2021
$192kBLRD VA IK6 BX005234BLRD VA IK6 BX005238Medical Research Council MR/J002895/1Medical Research Council MR/M012573/1Medical Research Council MR/P020941/1NIA NIH HHS AG050676NIA NIH HHS AG051442NIA NIH HHS K99 AG064143NIA NIH HHS P01 AG051442NIA NIH HHS R00 AG064143NIA NIH HHS R01 AG050676
Abstract
Age-associated loss of muscle mass and function (sarcopenia) has a profound effect on the quality of life in the elderly. Our previous studies show that CuZnSOD deletion in mice (Sod1
Indexed as
AnimalsCopperMiceMotor NeuronsPhenotypeSuperoxide Dismutase-1ZincCopperSuperoxide Dismutase-1ZincagingCuZnSODdenervationmotor neuronsarcopenia
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.