Evidence map›Paper›PMID 32886853›Full record

ArticleJournal of thrombosis and haemostasis : JTH2020

Impact of different anticoagulation management strategies on outcomes in atrial fibrillation: Dutch and Belgian results from the GARFIELD-AF registry.

Jaap Seelig, Martin E W Hemels, Olivier Xhaët, Maarten C M Bongaerts, Axel de Wolf, Björn E Groenemeijer, Alex Heyse, Pieter Hoogslag, Joeri Voet, Jean-Paul R Herrman and 17 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Contemporary management of patients with atrial fibrillation in the Netherlands and Belgium: a report from the EORP-AF long-term general registry.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2021
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 19 institutions in 3 countries.

Jaap SeeligRijnstate, Arnhem, the Netherlands.ORCID https://orcid.org/0000-0003-0191-0244
Martin E W HemelsRijnstate, Arnhem, the Netherlands.
Olivier XhaëtCHU UCL Namur, Mont-Godinne, Yvoir, Belgium.
Maarten C M BongaertsAnticoagulation Clinic, Ziekenhuis Rivierenland, Tiel, the Netherlands.
Axel de WolfRZ Heilig Hart, Tienen, Belgium.
Björn E GroenemeijerGelre Ziekenhuizen, Apeldoorn-Zutphen, the Netherlands.
Alex HeyseAZ Glorieux, Ronse, Belgium.
Pieter HoogslagIsala Diaconessenhuis, Meppel, the Netherlands.
Joeri VoetAZ Nikolaas, Sint-Niklaas, Belgium.
Jean-Paul R HerrmanOnze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands.
Geert VervoortAZ Sint-Maarten, Mechelen, Belgium.
Walter HermansElisabeth-TweeSteden Ziekenhuis, Tilburg, the Netherlands.
Bart WollaertZNA Stuivenberg, Antwerpen, Belgium.
Lucas V A BoersmaSt. Antonius Ziekenhuis, Nieuwegein, the Netherlands.
Kurt HermansAZ Sint-Lucas, Gent, Belgium.
Andreas LucassenSt. Jans Gasthuis, Weert, the Netherlands.
Stefan VerstraeteAZ Zeno, Knokke-Heist, Belgium.
Henk J AdriaansenGelre Ziekenhuizen, Apeldoorn-Zutphen, the Netherlands.
Georges H MairesseCliniques du Sud-Luxembourg, Arlon, Belgium.
Willem F TerpstraSlingeland Ziekenhuis, Doetinchem, the Netherlands.
Dirk FaesMariaziekenhuis Noord-Limburg, Overpelt, Belgium.
Mathijs PieterseStichting Cardiologie Amsterdam, Amsterdam, the Netherlands.
Saverio VirdoneThrombosis Research Institute, London, UK.
Freek W A VerheugtOnze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands.
Frank CoolsAZ Klina, Brasschaat, Antwerpen, Belgium.
Hugo Ten CateCardiovascular Research Institute Maastricht, Maastricht, the Netherlands.
GARFIELD-AF investigators
Gelre Hospitals · NLMaastricht University · NLOLVG · NLAZ Klina · BEAZ Sint-Lucas · BEAZ Sint-Lucas · BECHU Dinant Godinne UCL Namur · BECliniques du Sud Luxembourg · BEElisabeth-TweeSteden Ziekenhuis · NLIsala · NLMariaziekenhuis · BERadboud University Nijmegen · NLSlingeland Ziekenhuis · NLSt. Antonius Ziekenhuis · NLSt.Jans Gasthuis Weert · NLThrombosis Research Institute · GBVlaamse Vereniging voor Obstetrie en Gynaecolo · BEZiekenhuisnetwerk Antwerpen Stuivenberg · BEZiekenhuis Rivierenland · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe uptake rate of non-vitamin K oral anticoagulants (NOAC) for the treatment of non-valvular atrial fibrillation (AF) was far lower in the Netherlands (NL) compared to Belgium (BE). Also, patients on VKA in NL were treated with a higher target international normalized ratio (INR) range of 2.5 to 3.5.

objectivesTo explore the effect of these differences on thromboembolism (TE) and bleeding.

methodsData from the GARFIELD-AF registry was used. Patients with new-onset AF and ≥1 investigator-determined risk factor for stroke were included between 2010 and 2016. Event rates from 2 years of follow-up were used.

resultsIn NL and BE, 1186 and 1705 patients were included, respectively. Female sex (42.3% vs 42.2%), mean age (70.7 vs 71.3 years), CHA

conclusionsIn GARFIELD-AF, despite similar characteristics, patients on anticoagulants were treated differently in NL and BE. Although the rate of major bleeding was 33% higher in NL, variations in bleeding, mortality, and TE rates were not statistically significant.

Indexed as

Atrial FibrillationStrokeAdministration, OralAgedAnticoagulantsBelgiumFemaleHumansNetherlandsRegistriesRisk FactorsVitamin KAnticoagulantsVitamin Kanticoagulantshemorrhageinternational normalized ratioregistriesstroke

Identifiers

PMID32886853
PMCPMC7756514
OpenAlexW3083127140

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.