ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2020
Predictors of Olfactory Decline in Aging: A Longitudinal Population-Based Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
- Epidemiology of olfactory dysfunction in China: a nationwide population-based cross-sectional study.Annals of medicine · 2026Article
- Blood-based biomarkers of Alzheimer's disease and olfactory decline over 15 years in older adults.GeroScience · 2026Article
- High Pesticide Exposure Events and Self-Reported and Measured Olfactory Dysfunction.JAMA otolaryngology-- head & neck surgery · 2026Article
- The Diabetic Nose: A Narrative Review of Rhinologic Involvement in Diabetes (1973-2025).Journal of clinical medicine · 2026Review
- Olfaction and Coronary Heart Disease.JAMA otolaryngology-- head & neck surgery · 2026Article
- Cerebral Small Vessel Disease in Older Adults With Olfactory Dysfunction.International forum of allergy & rhinology · 2025Article
- Contributions and future potential of animal models for geroscience research on sensory systems.GeroScience · 2025Review
- Olfaction and diabetes among older adults.Chemical senses · 2025Article
- Global Poorer Olfaction, Frailty and Postoperative Adverse Outcomes: Exploring Their Interplay in a Prospective Cohort of Older Adults Undergoing Elective Surgery.Clinical interventions in aging · 2025Article
- Cerebrovascular burden and neurodegeneration linked to 15-year odor identification decline in older adults.Frontiers in aging neuroscience · 2025Article
- Persistent Post-COVID-19 Olfactory Dysfunction and Its Association with Autonomic Nervous System Function: A Case-Control Study.Diseases (Basel, Switzerland) · 2024Article
- Poor olfaction prior to cardiac surgery: Association with cognition, plasma neurofilament light, and post-operative delirium.International journal of geriatric psychiatry · 2024Article
- An experimental framework for conjoint measures of olfaction, navigation, and motion as pre-clinical biomarkers of Alzheimer's disease.Journal of Alzheimer's disease reports · 2024Review
- Factors influencing olfactory function in an adult general population sample: the CHRIS study.Chemical senses · 2024Article
- Odor Identification Across Time in Mutation Carriers and Non-Carriers in Autosomal-Dominant Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Article
- Factors Associated with Poor Olfaction and Olfactory Decline in Older Adults in the ARIC Neurocognitive Study.Nutrients · 2023Article
- Olfaction in (Social) Context: The Role of Social Complexity in Trajectories of Older Adults' Olfactory Abilities.Journal of aging and health · 2023Article
- Environmental Air Pollution and Olfactory Decline in Aging.Environmental health perspectives · 2022Article
- Olfactory Dysfunction: A Complication of Diabetes or a Factor That Complicates Glucose Metabolism? A Narrative Review.Journal of clinical medicine · 2021Review
- Olfactory Bulb Proteomics Reveals Widespread Proteostatic Disturbances in Mixed Dementia and Guides for Potential Serum Biomarkers to Discriminate Alzheimer Disease and Mixed Dementia Phenotypes.Journal of personalized medicine · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOlfactory dysfunction is common in aging and associated with dementia and mortality. However, longitudinal studies tracking change in olfactory ability are scarce. We sought to identify predictors of interindividual differences in rate of olfactory identification change in aging.
methodParticipants were 1780 individuals, without dementia at baseline and with at least 2 olfactory assessments over 12 years of follow-up (mean age = 70.5 years; 61.9% female), from the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K). Odor identification was assessed with the Sniffin' Sticks. We estimated the impact of demographic, health, and genetic factors on rate of olfactory change with linear mixed effect models.
resultsAdvancing age, manufacturing profession, history of cerebrovascular disease, higher cardiovascular disease burden, diabetes, slower walking speed, higher number of medications, and the APOE ε4 allele were associated with accelerated odor identification decline (ps < .014). Multi-adjusted analyses showed unique associations of age, diabetes, and ε4 to olfactory decline (ps < .017). In 1531 participants who remained free of dementia (DSM IV criteria) during follow-up, age, cardiovascular disease burden, and diabetes were associated with accelerated decline (ps < .011). Of these, age and diabetes remained statistically significant in the multi-adjusted model (ps < .001).
conclusionDemographic, vascular, and genetic factors are linked to rate of decline in odor identification in aging. Although some olfactory loss may be an inevitable part of aging, our results highlight the importance of vascular factors for the integrity of the olfactory system, even in the absence of dementia.
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