Evidence map›Paper›PMID 32886511›Full record

ArticleJournal of medicinal chemistry2020

DPAGT1 Inhibitors of Capuramycin Analogues and Their Antimigratory Activities of Solid Tumors.

Katsuhiko Mitachi, Rita G Kansal, Kirk E Hevener, Cody D Gillman, Syed M Hussain, Hyun Gi Yun, Gustavo A Miranda-Carboni, Evan S Glazer, William M Clemons, Michio Kurosu

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. DPAGT1-Perspective as an Anticancer Drug Target.Molecules (Basel, Switzerland) · 2025
    Review
  6. Article
  7. Concise Synthesis of Tunicamycin V and Discovery of a Cytostatic DPAGT1 Inhibitor.Angewandte Chemie (International ed. in English) · 2022
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Katsuhiko MitachiDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, Tennessee 38163, United States.
Rita G KansalDepartment of Surgery and Center for Cancer Research, College of Medicine, University of Tennessee Health Science Center, 910 Madison St., Suite 300, Memphis, Tennessee 38163, United States.
Kirk E HevenerDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, Tennessee 38163, United States.ORCID 0000-0002-5584-3625
Cody D GillmanDivision of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Blvd., Pasadena, California 91125, United States.
Syed M HussainDepartment of Surgery and Center for Cancer Research, College of Medicine, University of Tennessee Health Science Center, 910 Madison St., Suite 300, Memphis, Tennessee 38163, United States.
Hyun Gi YunDivision of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Blvd., Pasadena, California 91125, United States.ORCID 0000-0002-3508-5791
Gustavo A Miranda-CarboniDepartment of Medicine, Division of Hematology-Oncology, University of Tennessee Health Science Center, 19 S. Manassas Avenue, Memphis, Tennessee 38163, United States.
Evan S GlazerDepartment of Surgery and Center for Cancer Research, College of Medicine, University of Tennessee Health Science Center, 910 Madison St., Suite 300, Memphis, Tennessee 38163, United States.
William M ClemonsDivision of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Blvd., Pasadena, California 91125, United States.
Michio KurosuDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, Tennessee 38163, United States.ORCID 0000-0003-0092-0619
University of Tennessee Health Science Center · USCalifornia Institute of Technology · US

Funding

Mechanistic details of key integral-membrane enzymes for antimicrobial discoveryR01GM114611 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI William M. Clemons, Michio Kurosu · 2016 to 2026
$4.2M
NIGMS NIH HHS R01 GM114611
6 · The paper itself

Abstract

Capuramycin displays a narrow spectrum of antibacterial activity by targeting bacterial translocase I (MraY). In our program of development of new

Indexed as

AminoglycosidesAntineoplastic AgentsCell Line, TumorCell MovementDrug SynergismEnzyme InhibitorsHumansN-AcetylglucosaminyltransferasesNeoplasmsPaclitaxelSnail Family Transcription FactorsStructure-Activity RelationshipAminoglycosidesAntineoplastic Agentscapuramycindolichyl-phosphate alpha-N-acetylglucosaminyltransferaseEnzyme InhibitorsN-AcetylglucosaminyltransferasesPaclitaxelSNAI1 protein, humanSnail Family Transcription Factors

Identifiers

PMID32886511
PMCPMC7554145
OpenAlexW3083349772

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.