Evidence map›Paper›PMID 32886469›Full record

ArticleCritical care medicine2020

National Trends and Variation of Functional Status Deterioration in the Medically Critically Ill.

Nicholas E Ingraham, Victor Vakayil, Kathryn M Pendleton, Alexandria J Robbins, Rebecca L Freese, Elise F Northrop, Melissa E Brunsvold, Anthony Charles, Jeffrey G Chipman, Christopher J Tignanelli

Open access · greenAbstract read
In one paragraph

Article in Critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

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  9. Discordant Cardiopulmonary Resuscitation and Code Status at Death.Journal of pain and symptom management · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Nicholas E IngrahamDepartment of Medicine, University of Minnesota Medical School, Minneapolis, MN.
Victor VakayilSchool of Public Health, University of Minnesota, Minneapolis, MN.
Kathryn M PendletonDepartment of Medicine, University of Minnesota Medical School, Minneapolis, MN.
Alexandria J RobbinsDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN.
Rebecca L FreeseBiostatistical Design and Analysis Center, Clinical and Translational Science Institute, University of Minnesota, Minneapolis, MN.
Elise F NorthropBiostatistical Design and Analysis Center, Clinical and Translational Science Institute, University of Minnesota, Minneapolis, MN.
Melissa E BrunsvoldDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN.
Anthony CharlesDepartment of Surgery, University of North Carolina School of Medicine, Chapel Hill, NC.
Jeffrey G ChipmanDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN.
Christopher J TignanelliDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN.
University of Minnesota Medical Center · USUniversity of Minnesota · USUniversity of North Carolina at Chapel Hill · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
TRAINING-PULMONARY CELL &MOLECULAR BIOLOGY &PHYSIOLOGYT32HL007741 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI DUDLEY, R. ADAMS, INGBAR, DAVID H · 1994 to 2023
$13.9M
NCATS NIH HHS UL1 TR000114NCATS NIH HHS UL1 TR002494NHLBI NIH HHS T32 HL007741
6 · The paper itself

Abstract

objectivesPhysical and psychologic deficits after an ICU admission are associated with lower quality of life, higher mortality, and resource utilization. This study aimed to examine the prevalence and secular changes of functional status deterioration during hospitalization among nonsurgical critical illness survivors over the past decade.

designWe performed a retrospective longitudinal cohort analysis.

settingAnalysis performed using the Cerner Acute Physiology and Chronic Health Evaluation outcomes database which included manually abstracted data from 236 U.S. hospitals from 2008 to 2016. PATIENTS: We included nonsurgical adult ICU patients who survived their hospitalization and had a functional status documented at ICU admission and hospital discharge. Physical functional status was categorized as fully independent, partially dependent, or fully dependent.

interventionsNone. MEASUREMENTS AND MAIN

resultsFunctional status deterioration occurred in 38,116 patients (29.3%). During the past decade, functional status deterioration increased in each disease category, as well as overall (prevalence rate ratio, 1.15; 95% CI, 1.13-1.17; p < 0.001). Magnitude of functional status deterioration also increased over time (odds ratio, 1.03; 95% CI, 1.03-1.03; p < 0.001) with hematological, sepsis, neurologic, and pulmonary disease categories having the highest odds of severe functional status deterioration.

conclusionsFollowing nonsurgical critical illness, the prevalence of functional status deterioration and magnitude increased in a nationally representative cohort, despite efforts to reduce ICU dysfunction over the past decade. Identifying the prevalence of functional status deterioration and primary etiologies associated with functional status deterioration will elucidate vital areas for further research and targeted interventions. Reducing ICU debilitation for key disease processes may improve ICU survivor mortality, enhance quality of life, and decrease healthcare utilization.

Indexed as

Clinical DeteriorationFunctional StatusActivities of Daily LivingAgedAPACHECritical IllnessFemaleHumansIntensive Care UnitsLongitudinal StudiesMaleMiddle AgedPrevalenceQuality of LifeRetrospective StudiesUnited States

Identifiers

PMID32886469
PMCPMC8033631
OpenAlexW3047294514

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.