Evidence map›Paper›PMID 32886427›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2021

Synovial mesenchymal stem cells promote the meniscus repair in a novel pig meniscus injury model.

Nobutake Ozeki, Yuji Kohno, Yoshihisa Kushida, Naoto Watanabe, Mitsuru Mizuno, Hisako Katano, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya

Open access · hybridAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Identification and characterization of POSTNJournal of orthopaedic translation · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Nobutake OzekiCenter for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Yuji KohnoCenter for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Yoshihisa KushidaCenter for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Naoto WatanabeCenter for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Mitsuru MizunoCenter for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Hisako KatanoCenter for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Jun MasumotoFujifilm Corporation, Tokyo, Japan.
Hideyuki KogaDepartment of Joint Surgery and Sports Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Ichiro SekiyaCenter for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Tokyo, Japan.ORCID 0000-0002-6331-722X
Tokyo Medical and Dental University · JPFujifilm (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stem cell therapy has potential for the treatment of degenerative meniscus injuries; however, an optimal animal model has not been established. Basic and clinical research show that synovial mesenchymal stem cells (MSCs) promote meniscus repair. The purposes of this study were to create a novel meniscus injury model in microminipigs and to investigate the effectiveness of synovial MSCs on meniscus healing in this model. The posterior portion of the medial meniscus in microminipigs was punctuated 200 times with a 23G needle. Allogenic synovial MSC suspension was placed on the injury site for 10 min for transplantation. The meniscus was evaluated histologically and via sagittal magnetic resonance imaging (MRI), radial MRI reconstructed in three dimensional, and T2 mapping at 1 and 8 weeks. Proteoglycan content stained with safranin-o disappeared 1 week after treatment in both the MSC and control groups but increased at 8 weeks only in the MSC group. Histological scores at 8 weeks were significantly higher in the MSC group than in the control group (n = 6). At 8 weeks, the T2 values of the MSC group were significantly closer to those of a normal meniscus than were those of the control group. High signal intensity areas of the MRIs and positive areas stained with picrosirius red coincided with meniscal lesions. In conclusion, we created a novel meniscus injury model in microminipigs. Evaluation via histology, MRIs, and polarized microscopy showed that transplantation of synovial MSCs improved meniscus healing.

Indexed as

Mesenchymal Stem Cell TransplantationAnimalsSwineSwine, MiniatureSynovial MembraneTibial Meniscus Injuries3D MRImeniscusmeniscus injurymesenchymal stem cellssynoviumT2 mapping

Identifiers

PMID32886427
PMCPMC7821148
OpenAlexW3083732374

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.