Evidence map›Paper›PMID 32886294›Full record

ArticleNeurocritical care2021

Multifaceted Benefit of Whole Blood Versus Lactated Ringer's Resuscitation After Traumatic Brain Injury and Hemorrhagic Shock in Mice.

Benjamin E Zusman, Patrick M Kochanek, Zachary S Bailey, Lai Yee Leung, Vincent A Vagni, David O Okonkwo, Ava M Puccio, Lori A Shutter, Keri L Janesko-Feldman, Janice S Gilsdorf and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurocritical care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Benjamin E ZusmanUniversity of Pittsburgh School of Medicine, Scaife Hall, 3550 Terrace Street, Pittsburgh, PA, 15261, USA.ORCID http://orcid.org/0000-0003-2887-8934
Patrick M KochanekClinical and Translational Science Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Zachary S BaileyBrain Trauma Neuroprotection Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Lai Yee LeungBrain Trauma Neuroprotection Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Vincent A VagniDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
David O OkonkwoDepartment of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Ava M PuccioDepartment of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Lori A ShutterDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Keri L Janesko-FeldmanDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Janice S GilsdorfBrain Trauma Neuroprotection Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Deborah A ShearBrain Trauma Neuroprotection Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Ruchira M JhaClinical and Translational Science Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. ruchirajha@gmail.com.
University of Pittsburgh · USWalter Reed Army Institute of Research · USUniformed Services University of the Health Sciences · US

Funding

A Translational Evaluation of Sur1-Trpm4 Imaging Endophenotypes and Genetics to Direct Precision Medicine for Cerebral Edema After Traumatic Brain InjuryR01NS115815 · NINDS · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · PI JHA, RUCHIRA MENKA · 2021 to 2025
$2.8M
Translational assessment of sulfonylurea receptor-1 as a biomarker and therapeutic target for cerebral edema in traumatic brain injuryK23NS101036 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JHA, RUCHIRA MENKA · 2017 to 2021
$944k
NINDS NIH HHS K23 NS101036NINDS NIH HHS R01 NS115815
6 · The paper itself

Abstract

backgroundDespite increasing use in hemorrhagic shock (HS), whole blood (WB) resuscitation for polytrauma with traumatic brain injury (TBI) is largely unexplored. Current TBI guidelines recommend crystalloid for prehospital resuscitation. Although WB outperforms lactated Ringer's (LR) in increasing mean arterial pressure (MAP) in TBI + HS models, effects on brain tissue oxygenation (PbtO

methodsC57BL/6 mice (n = 72) underwent controlled cortical impact followed by HS (MAP = 25-27 mmHg). Ipsilateral hippocampal PbtO

resultsLR requirements in WB

conclusionWB resuscitation after TBI + HS results in robust improvements in brain oxygenation while minimizing fluid volume when compared to standard LR resuscitation. WB resuscitation may allow for a lower prehospital MAP without compromising brain oxygenation when compared to LR resuscitation. Further studies evaluating the effects of these physiologic benefits on outcome after TBI with HS are warranted, to eventually inform clinical trials.

Indexed as

Brain Injuries, TraumaticShock, HemorrhagicAnimalsDisease Models, AnimalIsotonic SolutionsMiceMice, Inbred C57BLResuscitationRinger's LactateIsotonic SolutionsRinger's LactateBrain injuriesHemorrhagicMultiple traumaResuscitationShockTraumatic

Identifiers

PMID32886294
PMCPMC8054986
OpenAlexW3083603937

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.