Evidence map›Paper›PMID 32886236›Full record

ArticleArchives of gynecology and obstetrics2021

Genetic variants in the glucocorticoid pathway genes and birth weight.

Michael O Schneider, Theresa Hübner, Jutta Pretscher, Tamme W Goecke, Judith Schwitulla, Lothar Häberle, Johannes Kornhuber, Arif B Ekici, Matthias W Beckmann, Peter A Fasching and 1 more

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Article in Archives of gynecology and obstetrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Michael O SchneiderDepartment of Gynecology and Obstetrics, Erlangen University Perinatal Center, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054, Erlangen, Germany. michael.schneider@uk-erlangen.de.ORCID 0000-0002-7583-307X
Theresa HübnerDepartment of Gynecology and Obstetrics, Erlangen University Perinatal Center, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054, Erlangen, Germany.
Jutta PretscherDepartment of Gynecology and Obstetrics, Erlangen University Perinatal Center, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054, Erlangen, Germany.
Tamme W GoeckeDepartment of Gynecology and Obstetrics, Erlangen University Perinatal Center, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054, Erlangen, Germany.
Judith SchwitullaBiostatistics Unit, Department of Gynecology and Obstetrics, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
Lothar HäberleBiostatistics Unit, Department of Gynecology and Obstetrics, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
Johannes KornhuberDepartment of Psychiatry, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
Arif B EkiciInstitute of Human Genetics, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
Matthias W BeckmannDepartment of Gynecology and Obstetrics, Erlangen University Perinatal Center, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054, Erlangen, Germany.
Peter A FaschingDepartment of Gynecology and Obstetrics, Erlangen University Perinatal Center, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054, Erlangen, Germany.
Eva SchwenkeDepartment of Gynecology and Obstetrics, Erlangen University Perinatal Center, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054, Erlangen, Germany.
Friedrich-Alexander-Universität Erlangen-Nürnberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to examine associations between single nucleotide polymorphisms (SNPs) that tag genetic variation in the glucocorticoid pathways (particularly in maternal genes FKBP5, NR3C1, and CRHR1) and birth weight.

methodsThe Franconian Maternal Health Evaluation Study (FRAMES) recruited healthy pregnant women prospectively for the assessment of maternal and fetal health. Germline DNA was collected from 375 pregnant women. Nine SNPs in the above-mentioned genes were genotyped. After reconstruction of haplotypes for each gene, a linear regression model was applied to the data to describe the association between haplotypes and birth weight.

resultsFemale sex in the newborn (compared to male) was associated with lower birth weight, whereas a later week of gestation, higher body mass index pre-pregnancy, and higher parity were associated with higher birth weight. No association with birthweight was shown for the haplotypes of the selected SNPs.

conclusionsIn this cohort of healthy unselected pregnant women, the analyzed candidate haplotypes in FKBP5, NR3C1, and CRHR1 did not show any association with birth weight. This might be in line with several other studies that have found no influence of fetal polymorphisms in the glucocorticoid receptor gene or triggers of the maternal HPA axis such as stress and psychosocial problems on birth weight. However, the small sample size in this study and the lack of consideration of individual risk factors and levels of stress in this cohort needs to be taken into account when interpreting the results.

Indexed as

Birth WeightAdultCohort StudiesCRF Receptor, Type 1FemaleGenotypeGlucocorticoidsHaplotypesHumansHypothalamo-Hypophyseal SystemInfant, NewbornMalePituitary-Adrenal SystemPolymorphism, Single NucleotidePregnancyReceptors, Corticotropin-Releasing HormoneCRF Receptor, Type 1GlucocorticoidsNR3C1 protein, humanReceptors, Corticotropin-Releasing HormoneReceptors, GlucocorticoidTacrolimus Binding Protein 5Tacrolimus Binding ProteinsBirth weightCRHR1FKBP5NR3C1Single nucleotide polymorphisms

Identifiers

PMID32886236
OpenAlexW3083510142

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.