Evidence map›Paper›PMID 32886189›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2021

Five-year follow-up results of aerobic and impact training on bone mineral density in early breast cancer patients.

L Vehmanen, H Sievänen, P Kellokumpu-Lehtinen, R Nikander, R Huovinen, J Ruohola, H M Penttinen, M Utriainen, K Tokola, C Blomqvist and 1 more

Open access · hybridAbstract read
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In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Long-term effects of exercise interventions on physical activity in breast cancer patients: a systematic review and meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  3. Pooled it
  4. The effects of exercise on the bone health of people with cancer: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Pooled it
  5. Trial
  6. Article
  7. Article
  8. Review
  9. Observational
  10. Review
  11. Article
  12. Review
  13. Mechanobiology of Bone Metastatic Cancer.Current osteoporosis reports · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

L VehmanenDepartment of Oncology, Helsinki University Central Hospital, Comprehensive Cancer Center and University of Helsinki, Helsinki, Finland. leena.vehmanen@hus.fi.ORCID http://orcid.org/0000-0003-0123-1313
H SievänenThe UKK Institute for Health Promotion Research, Tampere, Finland.
P Kellokumpu-LehtinenDepartment of Oncology, Faculty of Medicine, Tampere University Central Hospital, University of Tampere, Tampere, Finland.
R NikanderDepartment of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
R HuovinenDepartment of Oncology, Turku University Central Hospital, Turku, Finland.
J RuoholaDepartment of Oncology, Turku University Central Hospital, Turku, Finland.
H M PenttinenCancer Society of Pirkanmaa, Tampere, Finland.
M UtriainenDepartment of Oncology, Helsinki University Central Hospital, Comprehensive Cancer Center and University of Helsinki, Helsinki, Finland.
K TokolaThe UKK Institute for Health Promotion Research, Tampere, Finland.
C BlomqvistDepartment of Oncology, Helsinki University Central Hospital, Comprehensive Cancer Center and University of Helsinki, Helsinki, Finland.
T SaartoDepartment of Oncology, Helsinki University Central Hospital, Comprehensive Cancer Center and University of Helsinki, Helsinki, Finland.
University of Helsinki · FITurku University Hospital · FIUrho Kaleva Kekkonen Institute · FICancer Society of Finland · FITampere University · FIUniversity of Jyväskylä · FI

Funding

Cancer Society of Finland ?Finnish Cultural Foundation and Medical Fund of the Pirkanmaa Hospital District ?Finska Läkaresällskapet ?Helsinki University Central Hospital ?The Academy of Finland ?The Finnish Breast Cancer Group ?The Finnish Cancer Foundation ?The Finnish Ministry of Education ?The Helander Foundation ?The Paulo Foundation ?The Social Insurance Institution of Finland ?
6 · The paper itself

Abstract

A 12-month exercise program reversibly prevented hip bone loss in premenopausal women with early breast cancer. The bone-protective effect was maintained for 2 years after the end of the program but was lost thereafter. PURPOSE: Breast cancer survivors are at an increased risk for osteoporosis and fracture. This 5-year follow-up of a randomized impact exercise intervention trial evaluated the maintenance of training effects on bone among breast cancer patients.

methodsFive hundred seventy-three early breast cancer patients aged 35-68 years and treated with adjuvant therapy were allocated into a 12-month exercise program or a control group. Four hundred forty-four patients (77%) were included in the 5-year analysis. The exercise intervention comprised weekly supervised step aerobics, circuit exercises, and home training. Areal bone mineral density (aBMD) was measured by dual-energy X-ray absorptiometry. Physical activity was estimated in metabolic equivalent (MET) hours per week and physical performance assessed by 2-km walking and figure-8 running tests.

resultsIn premenopausal patients, the 12-month exercise program maintained femoral neck (FN) and total hip (TH) aBMD for 3 years, but the protective effect was lost thereafter. The mean FN aBMD change in the exercise and control groups was - 0.2% and - 1.5% 1 year, - 1.1% and - 2.1% 3 years and - 3.3% versus - 2.4% 5 years after the beginning of the intervention, respectively. Lumbar spine (LS) bone loss was not prevented in premenopausal women and no training effects on aBMD were seen in postmenopausal women. The main confounding element of the study was the unexpected rise in physical activity among patients in the control group. The physical performance improved among premenopausal women in the exercise group compared with the controls.

conclusionThe 12-month exercise program prevented FN and TH bone loss in premenopausal breast cancer patients for 3 years. The bone-protective effect was reversible and lost thereafter.

Indexed as

Bone DensityBreast NeoplasmsAbsorptiometry, PhotonAdultAgedFemaleFemur NeckFollow-Up StudiesHumansMiddle AgedBone densityBreast cancerOsteoporosisPhysical activityTrainingWeight-bearing impact aerobic exercise

Identifiers

PMID32886189
PMCPMC7929955
OpenAlexW3083174561

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.