SynthesisInternational orthopaedics2021
What are the outcomes of core decompression without augmentation in patients with nontraumatic osteonecrosis of the femoral head?
Synthesis in International orthopaedics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Outcomes of surgical management for tarsal coalitions: a systematic review.Archives of orthopaedic and trauma surgery · 2023Pooled it
- One in five patients require conversion to arthroplasty after non-vascularized bone grafts in patients with osteonecrosis of the femoral head: a systematic review.Journal of orthopaedic surgery and research · 2023Pooled it
- Hip Arthroscopy With Triangular Drilling and Suction Decompression for Osteonecrosis of the Femoral Head: A Retrospective Study.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Prevalence of Osteonecrosis of the Femoral Head in High-Risk Male Patients with Severe COVID-19 Treated with High-Dose Corticosteroids: A Prospective Cohort Study Using Screening MRI-How Many Have Been Left Behind?Diagnostics (Basel, Switzerland) · 2026Article
- Article
- Dexras1 plays a crucial role in glucocorticoid-induced osteonecrosis of the femoral head by mediating imbalance between osteogenesis and adipogenesis.Cellular and molecular life sciences : CMLS · 2026Article
- Analysis of the efficacy of autologous adipose-derived stromal vascular fraction and calcium phosphate bone cement combined with core decompression in patients with femoral head necrosis: a retrospective study.BMC musculoskeletal disorders · 2026Article
- A retrospective comparison of hyperbaric oxygen and core decompression for mild to moderate avascular necrosis of the femoral head.Medical gas research · 2026Article
- The fate of bone marrow edema after core decompression and bone marrow aspiration concentrate grafting for the hip.BMC musculoskeletal disorders · 2025Article
- Concomitant Hip Arthroscopy Is Associated With Improved Outcomes of Core Decompression for Osteonecrosis of the Femoral Head: A Systematic Review.Arthroscopy, sports medicine, and rehabilitation · 2025Review
- The bibliometric and visualization analysis of alcohol-induced osteonecrosis of the femoral head: research trends and future directions (1998-2024).Journal of orthopaedic surgery and research · 2025Article
- Autologous Microfragmented Adipose Tissue Injection Combined With Core Decompression for Treatment of Early-Stage Osteonecrosis of the Femoral Head.Arthroscopy techniques · 2025Article
- 3D-printed manganese dioxide incorporated scaffold promotes osteogenic-angiogenic coupling for refractory bone defect by remodeling osteo-regenerative microenvironment.Bioactive materials · 2025Article
- Healing beyond bone: a qualitative study of the core decompression experience of physically active patients with stage II hip avascular necrosis.Journal of orthopaedic surgery and research · 2025Article
- Precollapse femoral head avascular necrosis after combined surgical-medical management.Bioinformation · 2025Article
- Outcomes of single-incision-augmented core decompression using trochanteric autograft in osteonecrosis of femoral head-a mean 5-year follow-up study.Journal of hip preservation surgery · 2024Article
- Evaluation of Safety and Efficacy of Cell Therapy Based on Osteoblasts Derived from Umbilical Cord Mesenchymal Stem Cells for Osteonecrosis of the Femoral Head: Study Protocol for a Single-Center, Open-Label, Phase I Clinical Trial.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Efficacy study of platelet-rich plasma combined with core decompression and bone grafting in the treatment of early-stage avascular necrosis of the femoral head: a retrospective study.BMC musculoskeletal disorders · 2024Article
- Less Acetabular Coverage Predicts the Failure of Core Decompression for Osteonecrosis of the Femoral Head: A Retrospective Cohort Study.Orthopaedic surgery · 2024Article
- Proteomic profiling of extracellular vesicles derived from human serum for the discovery of biomarkers in Avascular necrosis.Clinical proteomics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCore decompression (CD) of the femoral head is performed to preserve the hip in avascular necrosis (AVN). The outcome following this procedure differs based on the medical centre and the technique. Also, the time to total hip replacement (THR) and the percentage of patients subsequently undergoing a THR are controversial.
methodsA systematic review was performed following PRISMA guidelines. The search included CENTRAL, MEDLINE, EMBASE, Scopus, AMED and Web of Science Core Collection databases. Studies reporting the outcome of CD for AVN were assessed. Studies using additional implants, vascularized grafts or any type of augmentation were excluded. Quality assessment was performed using the Joanna Briggs Institute Critical Appraisal Checklist (JBI CAC) tool.
trial registrationInternational prospective register of systematic reviews (PROSPERO) - CRD42018100596 .
resultsA total of 49 studies describing 2540 hips were included. The mean weighted follow-up time was 75.1 months and the mean age at surgery was 39 years. Twenty-four of 37 studies reported improvement in all outcome scores, whilst 9/37 studies report only partial improvement post-operatively. Four studies (4/37) described poor clinical outcomes following intervention. Data was pooled from 20 studies, including 1134 hips with a weighted mean follow-up of 56 months. The percentage of hips undergoing THR averaged 38%. The time to THR had a weighted mean of 26 months after CD.
conclusionPooled results from 1134 hips and of these nearly 80% with early stage of osteonecrosis, showed that approximately 38% of patients underwent a total hip replacement at an average of 26 months following core decompression without augmentation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.