ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2020
IL-33 enhances macrophage release of IL-1β and promotes pain and inflammation in gouty arthritis.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Protectin DX reduces inflammatory pain initiated by superoxide anion in mice: targeting leukocyte recruitment, oxidative stress, cytokine production and TRPV1Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- IL-33 blockade attenuates vascular inflammation in a mouse model of Kawasaki disease vasculitis.Clinical and experimental immunology · 2026Article
- Article
- Oxygen-releasing microneedles enhance the therapeutic effect of corneal ectasia by increasing corneal oxygen content and riboflavin concentration during cross-linking.Materials today. Bio · 2025Article
- Study on the Predictive Value of Inflammatory Factors and Biomarkers in Synovial Fluid for Disease Progression in Knee Osteoarthritis Patients.Journal of musculoskeletal & neuronal interactions · 2025Article
- Genome-wide association study of common side effects following COVID-19 booster vaccination in a cohort of corporate employees in Japan.Scientific reports · 2025Article
- Exploring macrophage and nerve interaction in endometriosis-associated pain: the inductive role of IL-33.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Review
- Alveolar macrophages and monocyte subpopulations duringHeliyon · 2024Article
- Peripheral Mechanism of Cancer-Induced Bone Pain.Neuroscience bulletin · 2024Review
- Preparing a novel baicalin-loaded microemulsion-based gel for transdermal delivery and testing its anti-gout effect.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- To Investigate the Mechanism of Qinpi Tongfeng Formula in Treating Acute Gouty Arthritis by UHPLC-Q-Orbitrap-MS, Network Pharmacology and Experimental Validation.Journal of inflammation research · 2024Article
- IL-33/ST2 induces macrophage-dependent ROS production and TRPA1 activation that mediate pain-like responses by skin incision in mice.Theranostics · 2024Article
- Macrophages and microglia in inflammation and neuroinflammation underlying different pain states.Medical review (2021) · 2023Article
- Phospholipase A2 regulates autophagy in gouty arthritis: proteomic and metabolomic studies.Journal of translational medicine · 2023Article
- Decreased Peli1 expression attenuates osteoarthritis by protecting chondrocytes and inhibiting M1-polarization of macrophages.Bone & joint research · 2023Article
- Hesperidin Methyl Chalcone Reduces the Arthritis Caused by TiOMolecules (Basel, Switzerland) · 2023Article
- Mechanism of ShuiJingDan in Treating Acute Gouty Arthritis Flares Based on Network Pharmacology and Molecular Docking.Drug design, development and therapy · 2023Article
- Linalyl Acetate Ameliorates Mechanical Hyperalgesia Through Suppressing Inflammation by TSLP/IL-33 Signaling.Neurochemical research · 2022Article
- Effects of Gentiopicroside on activation of NLRP3 inflammasome in acute gouty arthritis mice induced by MSU.Journal of natural medicines · 2022Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo investigate the role of IL-33 in gouty arthritis. MATERIAL: 174 Balb/c (wild-type) and 54 ST2
methodsGout was induced by injection of monosodium urate (MSU) crystals in the knee joint of mice. Pain was determined using the electronic von Frey and static weight bearing. Neutrophil recruitment was determined by H&E staining, Rosenfeld staining slides, and MPO activity. ELISA was used for cytokine and sST2 measurement. The priming effect of IL-33 was determined in BMDM.
resultsSynovial fluid of gout patients showed higher IL-33 levels and neutrophil counts than osteoarthritis patients. In mice, the absence of ST2 prevented mechanical pain, knee joint edema, neutrophil recruitment to the knee joint, and lowered IL-1β and superoxide anion levels. In macrophages, IL-33 enhanced the release of IL-1β and TNF-α, and BMDMs from ST2
conclusionIL-33 mediates gout pain and inflammation by boosting macrophages production of cytokines upon MSU crystals stimulus.
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Registered trials
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