ArticlePlant biotechnology journal2021
The miR156/SPL module regulates apple salt stress tolerance by activating MdWRKY100 expression.
Article in Plant biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.
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Who cites it
111 citing papers in PubMed, 241 citations in OpenAlex.
- The bp-miR156c-BpSPL2 module positively regulates drought tolerance by mediating lateral root development and reactive oxygen species scavenging in Betula platyphylla.Plant cell reports · 2026Article
- An Analysis of the Early Responses to Low-Temperature Stress in Oil Palm Using Integrative Physiology and Proteomics.International journal of molecular sciences · 2026Article
- Advances in Physiological and Molecular Mechanisms of Heat Stress in Apple and Pear.Plants (Basel, Switzerland) · 2026Review
- The MdERF1B-MdWRKY75-MdSOS3 Module Confers Salt Tolerance by Regulating Sodium-Potassium Homoeostasis in Apple.Plant, cell & environment · 2026Article
- Splicing Factor SR45 Enhances Cold Tolerance in Cassava by Recruiting Nu4A Complex and Transcription Factors to Activate WRKY30.Plant, cell & environment · 2026Article
- Regulatory insights underlying apple to cold stress.Horticulture research · 2026Article
- Genome-Wide Identification and Expression Profiling of the SPL Gene Family inPlants (Basel, Switzerland) · 2026Article
- miRNA Profiling Reveals the Role of Gibberellin Signaling Pathway in Low-Nitrogen Stress Adaptation of Xinjiang Spring Wheat.Plants (Basel, Switzerland) · 2026Article
- Article
- ZmmiR1432-ZmCML21-ZmPMA2 Module Affects Maize Low Phosphate Tolerance via Regulating Organic Acid Secretion.Plant biotechnology journal · 2026Article
- Root-Specific Signal Modules Mediating Abiotic Stress Tolerance in Fruit Crops.Plants (Basel, Switzerland) · 2026Review
- Temporal dynamics of photosynthetic inhibition, antioxidant defense, and transcriptomic reprogramming in 'Crimson Seedless' grapevine under saline-alkali stress.Frontiers in plant science · 2026Article
- Flowering pathway genes: key targets for accelerated breeding in woody plants.Plant cell reports · 2025Review
- SQUAMOSA-Promoter Binding Protein Like 10/14 (OsSPL10/14) Regulate Salt Tolerance by Modulating Reactive Oxygen Species Homeostasis in Rice (Oryza Sativa L.).Rice (New York, N.Y.) · 2025Article
- Overexpression ofInternational journal of molecular sciences · 2025Article
- CaSBP12 is implicated in pepper's defense resistance to Phytophthora capsici infection associated with the SA signaling pathway.BMC plant biology · 2025Article
- Rice RING E3 Ligase OsRMT1 Negatively Regulates Salt Tolerance by Degrading the Canonical Salt-Responsive Protein OsMBL1.Plant biotechnology journal · 2025Article
- Genome-Wide Identification and Expression Analysis of thePlants (Basel, Switzerland) · 2025Article
- Article
- Recent advances in improving yield and immunity through transcription factor engineering.Journal of integrative plant biology · 2025Review
51 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Salt stress dramatically impedes plant growth and development as well as crop yield. The apple production regions are reduced every year, because of the secondary salt damage by improper fertilization and irrigation. To expand the cultivation area of apple (Malus domestica) and select salt-resistant varieties, the mechanism of salt tolerance in apple is necessary to be clarified. The miR156/SPL regulatory module plays key roles in embryogenesis, morphogenesis, life cycle stage transformation, flower formation and other processes. However, its roles in the mechanisms of salt tolerance are unknown. In order to elucidate the mechanism of 156/SPL regulating salt stress in apple, we performed RLM-5' RACE and stable genetic transformation technology to verify that both mdm-MIR156a and MdSPL13 responded to salt stress in apple and that the latter was the target of the former. MIR156a overexpression weakened salt resistance in apple whereas MdSPL13 overexpression strengthened it. A total of 6094 differentially expressed genes relative to nontransgenic apple plants were found by RNA-Seq analysis of MdSPL13OE. Further verification indicated that MdSPL13 targeted the MdWRKY100 gene promoter. Moreover, MdWRKY100 overexpression enhanced salt tolerance in apple. Our results revealed that the miR156/SPL module regulates salt tolerance by up-regulating MdWRKY100 in apple. This study is the first to elucidate the mechanism underlying the miRNA network response to salt stress in apple and provides theoretical and empirical bases and genetic resources for the molecular breeding of salt tolerance in apple.
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