Evidence map›Paper›PMID 32885720›Full record

ArticleNanomedicine (London, England)2020

Measurement and standardization challenges for extracellular vesicle therapeutic delivery vectors.

Bryant C Nelson, Samantha Maragh, Ionita C Ghiran, Jennifer C Jones, Paul C DeRose, Elzafir Elsheikh, Wyatt N Vreeland, Lili Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomedicine (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

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  16. Exosomes as immunomodulators in autoimmune inflammation: implications for primary Sjögren's disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bryant C NelsonNational Institute of Standards & Technology, Material Measurement Laboratory, Gaithersburg, MD 20899, USA.ORCID 0000-0001-8166-4121
Samantha MaraghNational Institute of Standards & Technology, Material Measurement Laboratory, Gaithersburg, MD 20899, USA.
Ionita C GhiranHarvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
Jennifer C JonesNational Institutes of Health, National Cancer Institute, Bethesda, MD 20892, USA.
Paul C DeRoseNational Institute of Standards & Technology, Material Measurement Laboratory, Gaithersburg, MD 20899, USA.
Elzafir ElsheikhNational Institute of Standards & Technology, Material Measurement Laboratory, Gaithersburg, MD 20899, USA.
Wyatt N VreelandNational Institute of Standards & Technology, Material Measurement Laboratory, Gaithersburg, MD 20899, USA.
Lili WangNational Institute of Standards & Technology, Material Measurement Laboratory, Gaithersburg, MD 20899, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs), such as exosomes and microvesicles, are nonreplicating lipid bilayer particles shed by most cell types which have the potential to revolutionize the development and efficient delivery of clinical therapeutics. This article provides an introduction to the landscape of EV-based vectors under development for the delivery of protein- and nucleic acid-based therapeutics. We highlight some of the most pressing measurement and standardization challenges that limit the translation of EVs to the clinic. Current challenges limiting development of EVs for drug delivery are the lack of: standardized cell-based platforms for the production of EV-based therapeutics; EV reference materials that allow researchers/manufacturers to validate EV measurements and standardized measurement systems for determining the molecular composition of EVs.

Indexed as

ExosomesExtracellular VesiclesNucleic AcidsDrug Delivery SystemsReference StandardsNucleic Acidsdrug deliveryexosomesextracellular vesiclesgene deliverymolecular compositionnucleic acidsprotein deliveryred blood cellsreference materialstherapeutics

Identifiers

PMID32885720
PMCPMC7546159

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.