ArticleJournal of diabetes investigation2021
Association of time in range, as assessed by continuous glucose monitoring, with painful diabetic polyneuropathy.
Article in Journal of diabetes investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Time in range, as measured by continuous glucose monitor, as a predictor of microvascular complications in type 2 diabetes: a systematic review.BMJ open diabetes research & care · 2022Pooled it
- Long-term efficacy of 10 kHz spinal cord stimulation in managing painful diabetic neuropathy: A post-study survey.Pain practice : the official journal of World Institute of Pain · 2025Trial
- Effects of Teneligliptin on HbA1c levels, Continuous Glucose Monitoring-Derived Time in Range and Glycemic Variability in Elderly Patients with T2DM (TEDDY Study).Diabetes & metabolism journal · 2022Trial
- Associations Between Sleep Quality and Continuous Glucose Monitoring-Derived Metrics in Individuals With Type 2 Diabetes.Journal of sleep research · 2026Article
- Association of continuous glucose monitoring metrics with early diabetic kidney disease in early-onset type 2 diabetes.Frontiers in endocrinology · 2026Article
- Pain alleviation in diabetic neuropathy using hybrid closed loop insulin pumps (PAINLESS) - A randomised crossover trial protocol.PloS one · 2026Article
- Impact of HbA1c variability and time-in-range fluctuations on large and small nerve fiber dysfunction in well-controlled type 2 diabetes: A prospective cohort observational study.Journal of diabetes investigation · 2025Observational
- Weight loss is associated with improved daytime time in range in adults with prediabetes and non-insulin-treated type 2 diabetes undergoing dietary intervention.Diabetic medicine : a journal of the British Diabetic Association · 2025Article
- Association of medication adherence and glycemic control with pain severity among patients with diabetes mellitus: a cross-sectional study from Palestine.BMC endocrine disorders · 2025Article
- Article
- Gut microbiota and its metabolites promote painful diabetic peripheral neuropathy complicated with cognitive dysfunction in mice.Frontiers in cellular and infection microbiology · 2025Article
- Glycemic variability's impact on painful diabetic peripheral neuropathy in type 2 diabetes patients.Scientific reports · 2024Article
- Future of Time-in-Range Goals in the Era of Advanced Hybrid Closed-Loop Automated Insulin Delivery Systems.Diabetes technology & therapeutics · 2024Article
- Noninvasive Diabetes Detection through Human Breath Using TinyML-Powered E-Nose.Sensors (Basel, Switzerland) · 2024Article
- Treatment of Painful Diabetic Neuropathy with 10 kHz Spinal Cord Stimulation: Long-Term Improvements in Hemoglobin A1c, Weight, and Sleep Accompany Pain Relief for People with Type 2 Diabetes.Journal of pain research · 2024Article
- The application of artificial intelligence in diabetic retinopathy: progress and prospects.Frontiers in cell and developmental biology · 2024Review
- Diabetic Peripheral Neuropathy and Glycemia Risk Index in Type 2 Diabetes: A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Use of Continuous Glucose Monitoring and Glucagon-Like Peptide 1 Receptor Agonist Therapy to Achieve Individualized Treatment Goals in Insulin-Treated People With Type 2 Diabetes: A Case Series and Expert Opinion.Clinical diabetes : a publication of the American Diabetes Association · 2024Article
- Association of HbA1c Variability with Vibrating Perception Threshold in Middle-Aged and Elderly Patients with Type 2 Diabetes Mellitus: A Retrospective Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Association between low-carbohydrate diets and continuous glucose monitoring-derived time in ranges.Journal of diabetes investigation · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
AIMS/
introductionThis study aimed to evaluate the association between time in range (TIR) obtained from continuous glucose monitoring and the prevalence and degree of painful diabetic neuropathy. MATERIALS AND
methodsA total of 364 individuals with diabetic peripheral neuropathy were enrolled in this study. Sensor-based flash glucose monitoring systems were used to monitor the participants' glucose levels, and the glycemic variability metrics were calculated, including the TIR, glucose coefficient of variation, standard deviation and the mean amplitude of glycemic excursions. The participants were asked to record any form of pain during the 2 weeks of monitoring, and score the pain every day on a numerical rating scale. Based on the numerical rating scale, the patients were divided into the pain-free group, mild pain group and moderate/severe pain group.
resultsOverall, 51.92% (189/364) of the participants were diagnosed with painful diabetic neuropathy. Compared with the pain-free group, the level of TIR decreased significantly in the mild pain and moderate/severe pain groups (P < 0.05). The prevalence of mild pain and moderate/severe pain decreased with increasing TIR quartiles (all P < 0.05). Multiple linear regression analysis showed that TIR was significantly negatively correlated with the numerical rating scale score after adjustment for glycated hemoglobin, glycemic variability indicators and other risk factors (P < 0.05). Logistic regression analysis showed that a decreasing level of TIR was significantly associated with an increasing risk of any pain and moderate/severe pain (P < 0.05).
conclusionsTIR is correlated with painful diabetic neuropathy and is underscored as a valuable clinical evaluation measure.
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