Evidence map›Paper›PMID 32885536›Full record

ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2021

Characterizing the regenerative capacity and growth patterns of the Texas blind salamander (Eurycea rathbuni).

Warren A Vieira, Kelsey Anderson, Lindsay Glass Campbell, Catherine D McCusker

Open access · greenAbstract read
In one paragraph

Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Warren A VieiraDepartment of Biology, University of Massachusetts, Boston, Massachusetts, USA.
Kelsey AndersonUnited States Fish and Wildlife Service, San Marcos Aquatic Resources Center, San Marcos, Texas, USA.
Lindsay Glass CampbellUnited States Fish and Wildlife Service, San Marcos Aquatic Resources Center, San Marcos, Texas, USA.
Catherine D McCuskerDepartment of Biology, University of Massachusetts, Boston, Massachusetts, USA.
United States Fish and Wildlife Service · USUniversity of Massachusetts Boston · US

Funding

The function of chromatin remodeling in the patterning of the salamander limb regenerateR15HD092180 · NICHD · UNIVERSITY OF MASSACHUSETTS BOSTON · PI MCCUSKER, CATHERINE D · 2018 to 2025
$1.5M
NICHD NIH HHS R15 HD092180
6 · The paper itself

Abstract

backgroundRegeneration of complex patterned structures is well described among, although limited to a small sampling of, amphibians. This limitation impedes our understanding of the full range of regenerative competencies within this class of vertebrates, according to phylogeny, developmental life stage, and age. To broaden the phylogenetic breath of this research, we characterized the regenerative capacity of the Texas blind salamander (Eurycea rathbuni), a protected salamander native to the Edwards Aquifer of San Marcos, Texas and colonized by the San Marcos Aquatic Resource Center. As field observations suggested regenerative abilities in this population, the forelimb stump of a live captured female was amputated in the hopes of restoring the structure, and thus locomotion in the animal. Tails were clipped from two males to additionally document tail regeneration.

resultsWe show that the Texas blind salamander exhibits robust limb and tail regeneration, like all other studied Plethodontidae. Regeneration in this species is associated with wound epithelium formation, blastema formation, and subsequent patterning and differentiation of the regenerate.

conclusionsThe study has shown that the Texas blind salamander is a valuable model to study regenerative processes, and that therapeutic surgeries offer a valuable means to help maintain and conserve this vulnerable species.

Indexed as

AnimalsCaudataCell DifferentiationFemaleForelimbMalePhylogenyRegenerationTailbreedingconserved regenerative mechanismlimb regenerationnonmodel organismtail regeneration

Identifiers

PMID32885536
PMCPMC8454265
OpenAlexW3083584617

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.