ArticleSurgery open science2020
Continuous thoracic spinal anesthesia with local anesthetic plus midazolam and ketamine is superior to local anesthetic plus fentanyl in major abdominal surgery.
Article in Surgery open science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- CT-guided thoracic cerebrospinal fluid puncture as an alternative approach when conventional approaches fail.Skeletal radiology · 2026Article
- Comparative Study on Clinical Outcomes of Posterior Endoscopic Cervical Foraminotomy under Local Anesthesia with Conscious Sedation and General Anesthesia.Journal of Korean Neurosurgical Society · 2026Article
- Comparison of postoperative pulmonary functions and outcomes in patients undergoing major abdominal surgeries between general anaesthesia with thoracic epidural and thoracic continuous spinal anaesthesia: An exploratory randomised study.Indian journal of anaesthesia · 2025Article
- Indications and Technique for Thoracic Segmental Spinal Anesthesia in Clinical Practice: A Narrative Review.Cureus · 2025Review
- Review
- Emergency Awake Laparotomy Using Neuraxial Anaesthesia: A Case Series and Literature Review.Journal of personalized medicine · 2024Article
- Comparison of block characteristics and outcomes in opioid-free and opioid-based thoracic continuous spinal anaesthesia in patients undergoing major abdominal surgery: A double-blinded randomised controlled trial.Indian journal of anaesthesia · 2024Article
- Neuraxial anesthesia for abdominal surgery, beyond the pandemic: a feasibility pilot study of 70 patients in a suburban hospital.Updates in surgery · 2023Article
- Segmental Thoracic Spinal Anesthesia for Laparoscopic Cholecystectomy with the "Hypobaric" Technique: A Case Series.Local and regional anesthesia · 2023Article
- NEW CONCEPT OF FUSION TECHNICS IN REGIONAL ANESTHESIA.Acta clinica Croatica · 2022Review
- Double neuraxial catheter (Subarachnoid and epidural) in obese patient cancer surgery: A case report.Annals of medicine and surgery (2012) · 2022Article
- Opioid-Free Segmental Thoracic Spinal Anesthesia with Intrathecal Sedation for Breast and Axillary Surgery: Report of Four Cases.Local and regional anesthesia · 2022Article
- The Double Face of Ketamine-The Possibility of Its Identification in Blood and Beverages.Molecules (Basel, Switzerland) · 2021Article
- Awake Major Abdominal Surgeries in the COVID-19 Era.Pain research & management · 2021Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLimited studies have applied thoracic continuous spinal anesthesia in abdominal surgery, relying exclusively on opioids. This retrospective study analyzes 2 different schemes of thoracic continuous spinal anesthesia and postoperative analgesia in elderly patients undergoing major abdominal surgery.
methodsA total of 98 patients aged ≥ 75 years were divided into 2 groups. The control group (60 patients) received bupivacaine plus fentanyl, whereas the study group (38 patients) received bupivacaine plus ketamine and midazolam. Both received analogous postoperative continuous intrathecal analgesia. Several perioperative variables were evaluated.
resultsSpinal anesthesia was performed without complications in all patients. Doses of noradrenaline administered, incidence of respiratory depression, need for intraoperative sedation, and time to first flatus were significantly reduced in the bupivacaine plus ketamine and midazolam group.
conclusionIn a population of frail, elderly patients, thoracic continuous spinal anesthesia with local anesthetic plus midazolam and ketamine was superior to local anesthetic plus fentanyl. In the group receiving local anesthetic plus midazolam and ketamine, the incidence of respiratory depression was reduced, and doses of norepinephrine and intraoperative sedating medications were lower. Intraoperative anesthesia and postoperative analgesia were similar in both groups.
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Registered trials
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