ArticleJHEP reports : innovation in hepatology2020
Similar performance of liver stiffness measurement and liver surface nodularity for the detection of portal hypertension in patients with hepatocellular carcinoma.
Article in JHEP reports : innovation in hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Diagnostic accuracy of transient elastography in diagnosing clinically significant portal hypertension in patients with chronic liver disease: a systematic review and meta-analysis.Journal of medical ultrasonics (2001) · 2022Pooled it
- Preliminary quantitative assessment of liver and spleen MR imaging and elastography in clinically significant portal hypertension.Scientific reports · 2026Article
- Quantitative Edge Analysis Can Differentiate Pancreatic Carcinoma from Normal Pancreatic Parenchyma.Diagnostics (Basel, Switzerland) · 2024Article
- Application of dynamic enhanced scanning with GD-EOB-DTPA MRI based on deep learning algorithm for lesion diagnosis in liver cancer patients.Frontiers in oncology · 2024Article
- Application of Ultrasound Elastography in Assessing Portal Hypertension.Diagnostics (Basel, Switzerland) · 2022Review
- Contrast-enhanced CT and liver surface nodularity for the diagnosis of porto-sinusoidal vascular disorder: A case-control study.Hepatology (Baltimore, Md.) · 2022Article
- Validation of the New Diagnostic Criteria for Clinically Significant Portal Hypertension by Platelets and Elastography.Digestive diseases and sciences · 2022Article
- Conventional and artificial intelligence-based imaging for biomarker discovery in chronic liver disease.Hepatology international · 2022Review
- Regenerating research and life.JHEP reports : innovation in hepatology · 2020Article
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
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Abstract
BACKGROUND &
aimsWe compare the performance of liver surface nodularity (LSN) and liver stiffness measurements (LSM) using transient elastography (TE) for the detection of clinically significant portal hypertension (CSPH) in patients with cirrhosis and hepatocellular carcinoma (HCC).
methodsAll patients with cirrhosis and HCC who underwent computed tomography, LSM and hepatic venous pressure gradient (HVPG) measurements within 30 days between 2015 and 2018 were included. The estimation of CSPH by LSN and LSM, and the LSM-spleen-size-to-platelet ratio score (LSPS) were evaluated and compared.
resultsIn total, 140 patients were included (109 men [78%], mean age 63 ± 9 years old), including 39 (28%) with CSPH. LSN measurements were valid in 130 patients (93%) and significantly correlated with HVPG (r = 0.68;
conclusionsThe diagnostic performance and feasibility of LSN measurements were similar to those of LSM for the detection of CSPH in patients with compensated cirrhosis and HCC. Combining LSN and LSPS accurately detected CSPH in >75% of patients. Such a combination could be useful in centres where the HVPG measurement is unavailable. LAY SUMMARY: The diagnostic performance and feasibility of liver surface nodularity was similar to that of liver stiffness measurement (LSM) for the detection of clinically significant portal hypertension in patients with compensated cirrhosis. Thus, liver surface nodularity could be an option for the preoperative detection of clinically significant portal hypertension in patients with hepatocellular carcinoma. Combining liver surface nodularity with LSM-spleen-size-to-platelet ratio score resulted in the accurate detection of clinically significant portal hypertension in >75% of patients, thus limiting the need for HVPG measurements.
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