Evidence map›Paper›PMID 32884996›Full record

ArticleGenes & diseases2020

CircRNA expression profiles in decidual tissue of patients with early recurrent miscarriage.

Chunli Li, Xuemei Chen, Xueqing Liu, Xiaoli Liu, Junlin He, Yubin Ding, Chao Tong, Chuan Peng, Yingxiong Wang, Rufei Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chunli LiLaboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, China.
Xuemei ChenLaboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, China.
Xueqing LiuLaboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, China.
Xiaoli LiuDepartment of Family Planning, Chongqing Health Center for Women and Children, Chongqing, 401174, PR China.
Junlin HeLaboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, China.
Yubin DingLaboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, China.
Chao TongJoint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, 400016, China.
Chuan PengLaboratory of Maternal and Fetal Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Yingxiong WangLaboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, China.
Rufei GaoLaboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) are a novel class of endogenous noncoding RNAs that play important roles in gene expression regulation. This study aimed to evaluate the potential role of circRNAs in decidual tissue of patients with early recurrent miscarriage (RM). We constructed circRNA expression profiles in decidual tissue using microarray data. A total of 123 differentially expressed circRNAs, including 78 upregulated and 45 downregulated circRNAs were detected in the early RM group compared with the control group (P < 0.05). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis also revealed the enrichment of specific circRNAs. The verified circRNA-targeted miRNA-mRNA network was constructed, most of the circRNAs harbored miRNA binding sites. The network involved 3 circRNAs, 27 microRNAs and 82 mRNAs. Hsa_circRNA_103092- miR-224-PRLR network was selected to verify by qRT-PCR. These results showed that circRNAs are aberrantly expressed in the decidual tissue in early RM patients and play potential roles in the development of early RM. It gives new insights into the mechanism of recurrent miscarriage.

Indexed as

Circular RNAsDecidual tissueEarly recurrent miscarriageExpression profilesMicroarray

Identifiers

PMID32884996
PMCPMC7452471

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.