ArticleJournal of immunology research2020
Comparative Analysis of the Occurrence and Role of CX3CL1 (Fractalkine) and Its Receptor CX3CR1 in Hemophilic Arthropathy and Osteoarthritis.
Article in Journal of immunology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Efficacy of oblique pulling manipulation combined with adjunct therapies (massage/acupuncture/herbal medicine/injection) for lumbar disc herniation: a systematic review and meta-analysis of pain and functional outcome.Frontiers in neurology · 2025Pooled it
- Clinical efficacy of a Chinese herbal gel plaster combined with manipulation for lumbar disc herniation: a prospective, randomized, double-blind, placebo-controlled trial.Frontiers in pharmacology · 2026Trial
- Effect of minimally invasive surgery guided by arthrography on surgical progress, postoperative recovery and long-term prognosis of lateral humeral condyle fractures in children: a retrospective cohort study.Translational pediatrics · 2026Article
- Reporting bias is prevalent in systematic reviews and meta-analyses related to endoscopicJournal of spine surgery (Hong Kong) · 2025Article
- Early-stage fusion and bone morphology process in anterior cervical discectomy and fusion: a comparison of autografts and allografts via quantitative computed tomography-based three-dimensional reconstruction.Quantitative imaging in medicine and surgery · 2025Article
- Personalized and precise prediction of cage width and implantation angle in transforaminal lumbar interbody fusion: an image analysis of combined application of CT and Surgimap.Quantitative imaging in medicine and surgery · 2025Article
- Developing a proactive coping theory-based conceptual framework for sarcopenia management in aging societies: a mixed-methods study from China.Frontiers in public health · 2025Article
- Biomarkers Involved in the Pathogenesis of Hemophilic Arthropathy.International journal of molecular sciences · 2024Review
- Exploring the interplay between paraspinal muscular status and bone health in osteoporosis and fracture risk: a comprehensive literature review on computed tomography (CT) and magnetic resonance imaging (MRI) studies.Quantitative imaging in medicine and surgery · 2024Review
- CX3CL1 (Fractalkine)-CX3CR1 Axis in Inflammation-Induced Angiogenesis and Tumorigenesis.International journal of molecular sciences · 2024Review
- OA-MEN: a fusion deep learning approach for enhanced accuracy in knee osteoarthritis detection and classification using X-Ray imaging.Frontiers in bioengineering and biotechnology · 2024Article
- Ferroptosis: a new target for iron overload-induced hemophilic arthropathy synovitis.Annals of hematology · 2023Article
- Exerkines and osteoarthritis.Frontiers in physiology · 2023Review
- Cross-Tissue Analysis Using Machine Learning to Identify Novel Biomarkers for Knee Osteoarthritis.Computational and mathematical methods in medicine · 2022Article
- Traumatic brain injury in mice induces changes in the expression of the XCL1/XCR1 and XCL1/ITGA9 axes.Pharmacological reports : PR · 2020Article
- Corrigendum to "Comparative Analysis of the Occurrence and Role of CX3CL1 (Fractalkine) and Its Receptor CX3CR1 in Hemophilic Arthropathy and Osteoarthritis".Journal of immunology research · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHemophilic arthropathy is characterized by recurrent bleeding episodes in patients with hemophilia leading to irreversible joint degeneration. The involvement of CX3CL1 (fractalkine) and its receptor CX3CR1 was observed in the pathogenesis of numerous arthritis-associated diseases. Taking this into account, we have presented a study investigating the role of the CX3CL1/CX3XR1 axis in the course of hemophilic arthropathy, including the CX3CL1-dependent expression of CD56
methodsThe study was carried out using cases (
resultsIn our study, we have documented increased average concentration of CX3CL1 in the blood serum of the study group (7.16 ± 0.53 ng/ml) compared to the control group (5.85 ± 0.70 ng/ml) without statistically significant difference in synovial fluid concentration at the same time. We have observed an increased macrophage presence with more marked proliferation and fibrosis of the synovial membrane in the study group. Remaining results such as expression of CX3CR1 presence of NK cells and larger surface area of blood vessels within the synovial membrane were noted also without statistical significance.
conclusionsThis study has demonstrated collective CX3CL1/CX3CR1 axis involvement in hemophilic arthropathy pathogenesis introducing new interesting diagnostics and a therapeutic target.
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