ArticleTranslational vision science & technology2020
Peripapillary Retinal Nerve Fiber Layer Profile in Relation to Refractive Error and Axial Length: Results From the Gutenberg Health Study.
Article in Translational vision science & technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Avoiding False-Positive Glaucoma Diagnosis in Myopic Eyes: Clinical Importance of OCT Scan Diameter.Journal of clinical medicine · 2026Article
- Optic Disc Characteristics in Children Born Preterm With and Without ROP: Results From the Gutenberg Prematurity Eye Study Young (GPESY).Investigative ophthalmology & visual science · 2025Observational
- Retinal nerve fiber layer thickness profile in an Iranian adult population.Scientific reports · 2025Article
- Long-Term Ocular Outcomes of Prematurity: Morphological Alterations, Visual Aspects and Implications for Age-Related Ocular Diseases.Journal of clinical medicine · 2025Review
- Normative Variability in Retinal Nerve Fiber Layer Thickness: Does It Matter Where the Peaks Are?Translational vision science & technology · 2025Article
- Article
- Update on the Utility of Optical Coherence Tomography in the Analysis of the Optic Nerve Head in Highly Myopic Eyes with and without Glaucoma.Journal of clinical medicine · 2023Review
- Asymmetry of Peripapillary Retinal Blood Vessel and Retinal Nerve Fiber Layer Thickness Between Healthy Right and Left Eyes.Investigative ophthalmology & visual science · 2023Article
- Asymmetry between right and left optical coherence tomography images identified using convolutional neural networks.Scientific reports · 2022Article
- Do biometric parameters improve the quality of optic nerve head measurements with spectral domain optical coherence tomography?BMC ophthalmology · 2022Article
- Asymmetry between right and left fundus images identified using convolutional neural networks.Scientific reports · 2022Article
- Alterations of optic tract and retinal structure in patients after thalamic stroke.Frontiers in aging neuroscience · 2022Article
- Enhanced Objective Detection of Retinal Nerve Fiber Bundle Defects in Glaucoma With a Novel Method for En Face OCT Slab Image Construction and Analysis.Translational vision science & technology · 2021Article
- Distribution and Classification of Peripapillary Retinal Nerve Fiber Layer Thickness in Healthy Young Adults.Translational vision science & technology · 2021Article
- Determinants of peripapillary retinal nerve fiber layer's grayscale value in normal eyes by spectral domain optical coherence tomography.Scientific reports · 2021Article
- Factors Associated with Changes in Peripapillary Retinal Nerve Fibre Layer Thickness in Healthy Myopic Eyes.Journal of ophthalmology · 2021Review
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To investigate the retinal nerve fiber layer profile measured by optical coherence tomography and its relation to refractive error and axial length. Methods: The Gutenberg Health Study is a population-based study in Mainz, Germany. At the five-year follow-up examination, participants underwent optical coherence tomography, objective refraction and biometry. Peripapillary retinal nerve fiber layer (pRNFL) was segmented using proprietary software. The pRNFL profiles were compared between different refraction groups and the angle between the maxima, i.e., the peaks of pRNFL thickness in the upper and lower hemisphere (angle between the maxima of pRNFL thickness [AMR]) was computed. Multivariable linear regression analysis was carried out to determine associations of pRNFL profile (AMR) including age, sex, optic disc size, and axial length in model 1 and spherical equivalent in model 2. Results: A total of 5387 participants were included. AMR was 145.3° ± 23.4° in right eyes and 151.8° ± 26.7° in left eyes and the pRNFL profile was significant different in the upper hemisphere. The AMR decreased with increasing axial length by -5.86°/mm (95% confidence interval [CI]: [-6.44; -5.29], Conclusions: The pRNFL profiles are related to individual ocular and systemic parameters. Translational Relevance: Biometric parameters should be considered when pRNFL profiles are interpreted in diagnostics, i.e., in glaucoma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.