ArticleTranslational vision science & technology2020
A Novel Quantitative Index of Meibomian Gland Dysfunction, the Meibomian Gland Tortuosity.
Article in Translational vision science & technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- The correlation between Demodex infestation and meibomian gland dysfunction at different ages.BMC ophthalmology · 2022Trial
- Information Entropy-Based Framework for Quantifying Curve Tortuosity in Meibomian Glands Uneven Atrophy.Translational vision science & technology · 2026Article
- Comparative diagnostic value of cylindrical dandruff and meibomian gland uneven atrophy forInternational journal of ophthalmology · 2026Article
- Keratoconjunctivitis Sicca in Sjögren Disease: Diagnostic Challenges and Therapeutic Advances.International journal of molecular sciences · 2025Review
- A modular and adaptable approach for automated morphological feature extraction in meibography images.Scientific reports · 2025Article
- Applied anatomy and morphology of Meibomian glands in the non-human primate.Scientific reports · 2025Article
- Investigation of early-stage cardiovascular-kidney-metabolic syndrome on retinal structure and function evaluated by optical coherence tomography angiography.Frontiers in medicine · 2025Article
- Crosslinking of tarsal collagen as a hypothetical therapy for dry eye disease.Medical hypothesis, discovery & innovation ophthalmology journal · 2025Article
- Quantitative evaluation of meibomian gland dysfunction via deep learning-based infrared image segmentation.Frontiers in artificial intelligence · 2025Article
- Association between tear lactoferrin, lysozyme, albumin levels, and obstructive sleep apnea syndrome: a cross-sectional study.Frontiers in medicine · 2025Article
- A Deep Learning Approach for Meibomian Gland Appearance Evaluation.Ophthalmology science · 2023Article
- Morphological changes in the meibomian gland in children with tic disorders.Quantitative imaging in medicine and surgery · 2023Article
- Meibomian Gland Dysfunction Clinical Practice Guidelines.Japanese journal of ophthalmology · 2023Article
- Effects of orthokeratology lenses on tear film and tarsal glands and control of unilateral myopia in children.Frontiers in cell and developmental biology · 2023Article
- Morphologic variants of Meibomian glands: age-wise distribution and differences between upper and lower eyelids.Frontiers in medicine · 2023Article
- Automatic identification of meibomian gland dysfunction with meibography images using deep learning.International ophthalmology · 2022Article
- Uneven Meibomian Gland Dropout in Patients with Meibomian Gland Dysfunction andJournal of clinical medicine · 2022Article
- Automation of dry eye disease quantitative assessment: A review.Clinical & experimental ophthalmology · 2022Review
- Meibomian Gland Density: An Effective Evaluation Index of Meibomian Gland Dysfunction Based on Deep Learning and Transfer Learning.Journal of clinical medicine · 2022Article
- Meibomian gland morphological changes in ocular herpes zoster patients based on AI analysis.Frontiers in cell and developmental biology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To quantitatively measure meibomian gland (MG) tortuosity in meibomian gland dysfunction (MGD) patients and normal controls and to observe the efficacy of evaluating MG tortuosity for the diagnosis of MGD. Methods: This cross-sectional study enrolled 32 obstructive MGD patients and 28 normal volunteers. Clinical assessments were performed, including symptom questionnaires, tear meniscus height, tear break-up time (TBUT), corneal fluorescein staining, lid margin abnormality, MG expressibility, and meibography. The meibomian gland tortuosity and meibomian gland density were measured by VIA software. Results: The mean age of the patients in the MGD group was 33.28 ± 9.28 years, and that of the normal controls was 25.25 ± 11.19 years. The average tortuosity of all MGs in the MGD patients was significantly larger than in the normal controls ( Conclusions: MG tortuosity is an effective index to delineate MG morphology and to diagnose MGD, especially for the diagnosis of early-stage MGD. Translation Relevance: Calculating tortuosity quantitatively may play an important role in the diagnosis of MGD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.