Evidence map›Paper›PMID 32884842›Full record

ArticleNPJ vaccines2020

Recombinant HA-based vaccine outperforms split and subunit vaccines in elicitation of influenza-specific CD4 T cells and CD4 T cell-dependent antibody responses in humans.

K A Richards, S Moritzky, I Shannon, T Fitzgerald, H Yang, A Branche, D J Topham, J J Treanor, J Nayak, Andrea J Sant

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 54 citations in OpenAlex.

  1. Randomised immunogenicity trial comparing 2019-2020 recombinant and egg-based influenza vaccines among frequently vaccinated healthcare personnel in Israel.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

K A RichardsDavid H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Ave, Box 609, Rochester, NY 14642 USA.
S MoritzkyDavid H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Ave, Box 609, Rochester, NY 14642 USA.ORCID 0000-0002-1904-3671
I ShannonDepartment of Pediatrics, Division of Infectious Diseases, University of Rochester Medical Center, 601 Elmwood Ave, Box 690, Rochester, NY 14642 USA.
T FitzgeraldDavid H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Ave, Box 609, Rochester, NY 14642 USA.
H YangDepartment of Biostatistics and Computational Biology, University of Rochester Medical Center, 265 Crittenden Blvd., Box 630, Rochester, NY 14642 USA.
A BrancheDepartment of Medicine, Division of Infectious Diseases, University of Rochester Medical Center, 601 Elmwood Ave., Box 689, Rochester, NY 14642 USA.
D J TophamDavid H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Ave, Box 609, Rochester, NY 14642 USA.ORCID 0000-0002-9435-8673
J J TreanorDepartment of Medicine, Division of Infectious Diseases, University of Rochester Medical Center, 601 Elmwood Ave., Box 689, Rochester, NY 14642 USA.
J NayakDepartment of Pediatrics, Division of Infectious Diseases, University of Rochester Medical Center, 601 Elmwood Ave, Box 690, Rochester, NY 14642 USA.
Andrea J SantDavid H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Ave, Box 609, Rochester, NY 14642 USA.ORCID 0000-0001-7176-7426
University of Rochester Medical Center · US

Funding

Multiple Chronic Conditions_Interdisciplinary Nurse Scientist TrainingT32NR015433 · NINR · CASE WESTERN RESERVE UNIVERSITY · PI MOORE, SHIRLEY M · 2015 to 2019
$1.9M
Automated Physiological Assessment of Chronic Pain in Daily LifeR21NR018972 · NINR · UNIVERSITY OF COLORADO · PI CEKO, MARTA · 2021 to 2022
$422k
NIAID NIH HHS HHSN272201400005CNINR NIH HHS R21 NR018972NINR NIH HHS T32 NR015433
6 · The paper itself

Abstract

Although traditional egg-based inactivated influenza vaccines can protect against infection, there have been significant efforts to develop improved formats to overcome disadvantages of this platform. Here, we have assessed human CD4 T cell responses to a traditional egg-based influenza vaccine with recently available cell-derived vaccines and recombinant baculovirus-derived vaccines. Adults were administered either egg-derived Fluzone

Indexed as

ImmunologyVaccines

Identifiers

PMID32884842
PMCPMC7450042
OpenAlexW3081381436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.