ReviewClinical and translational allergy2020
Initiating pollen sensitization - complex source, complex mechanisms.
Review in Clinical and translational allergy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
- Trial
- Common Ragweed Allergy Under Global Change Linking Invasion-Driven Aeroallergen Exposure with Molecular Sensitization and Allergic Airway Disease.Life (Basel, Switzerland) · 2026Review
- Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract-the B Cell Side.Allergy · 2026Review
- Genetic mechanisms of pollinosis: interactions between genes and environmental factors.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- Genome-Wide Blood DNA Methylation Profiling in Birch Pollen Allergic Patients Undergoing Allergen-Specific Immunotherapy.Allergy · 2025Article
- Cross-reactivity and sensitization profiles of cockroach and moth allergens provide new insights in cockroach-allergic patients.The World Allergy Organization journal · 2025Article
- The correlation between airborne pollen and asthma in children: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Article
- Combined exposure to shrimp tropomyosin and microbial components triggers enhanced allergic and inflammatory responsesFrontiers in allergy · 2025Article
- Associations of multiple lifestyle behaviors with allergic disease symptoms and sensitization in 9-11-year-old Finnish children.BMC pediatrics · 2024Article
- Modulation of Bronchial Epithelial Barrier Integrity by Low Molecular Weight Components from Birch Pollen.International journal of molecular sciences · 2024Article
- The Chemical Landscape of Leaf Surfaces and Its Interaction with the Atmosphere.Chemical reviews · 2024Review
- A systematic review of allergen cross-reactivity: Translating basic concepts into clinical relevance.The journal of allergy and clinical immunology. Global · 2024Review
- Shrimp Extract Exacerbates Allergic Immune Responses in Mice: Implications on Clinical Diagnosis of Shellfish Allergy.Clinical reviews in allergy & immunology · 2024Article
- Methylation-driven mechanisms of allergic rhinitis during pollen and non-pollen seasons using integrated bioinformatics analysis.Frontiers in genetics · 2024Article
- Recovering What Matters: High Protein Recovery after Endotoxin Removal from LPS-Contaminated Formulations Using Novel Anti-Lipid A Antibody Microparticle Conjugates.International journal of molecular sciences · 2023Article
- Chemical modification by peroxynitrite enhances TLR4 activation of the grass pollen allergen Phl p 5.Frontiers in allergy · 2023Article
- When the allergy alarm bells toll: The role of Toll-like receptors in allergic diseases and treatment.Frontiers in molecular biosciences · 2023Review
- Multiple-Cytokine Profiling: A Novel Method for Early Prediction of the Efficacy of Sublingual Immunotherapy in Allergic Rhinitis Patients.Journal of inflammation research · 2022Article
- Sensitisation to Pollen Allergens in Children and Adolescents of Different Ancestry Born and Living in the Same Area.Journal of asthma and allergy · 2022Article
- Newly defined allergens in the WHO/IUIS Allergen Nomenclature Database during 01/2019-03/2021.Allergy · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
Abstract
The mechanisms involved in the induction of allergic sensitization by pollen are not fully understood. Within the last few decades, findings from epidemiological and experimental studies support the notion that allergic sensitization is not only dependent on the genetics of the host and environmental factors, but also on intrinsic features of the allergenic source itself. In this review, we summarize the current concepts and newest advances in research focusing on the initial mechanisms inducing pollen sensitization. Pollen allergens are embedded in a complex and heterogeneous matrix composed of a myriad of bioactive molecules that are co-delivered during the allergic sensitization. Surprisingly, several purified allergens were shown to lack inherent sensitizing potential. Thus, growing evidence supports an essential role of pollen-derived components co-delivered with the allergens in the initiation of allergic sensitization. The pollen matrix, which is composed by intrinsic molecules (
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.