ArticleJournal of inflammation research2020
Peripheral Blood Inflammatory-Immune Cells as a Predictor of Infertility in Women with Polycystic Ovary Syndrome.
Article in Journal of inflammation research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Antinuclear Antibodies in Polycystic Ovary Syndrome: A Systematic Review of Observational Studies.International journal of molecular sciences · 2025Pooled it
- Potential Causal Association between Plasma Metabolites, Immunophenotypes, and Female Reproductive Disorders: A Two-Sample Mendelian Randomization Analysis.Biomolecules · 2024Pooled it
- Astragaloside IV alleviates chronic low-grade inflammation in polycystic ovary syndrome by acting on IL-6R and inhibiting the NLRP3 inflammasome.Scientific reports · 2026Article
- Inflammation at the crossroads of reproduction: SIRI as a prognostic signature of female infertility in hybrid regression-machine learning models.Archives of gynecology and obstetrics · 2026Article
- Neutrophils and NETosis in polycystic ovary syndrome: unraveling the immuno-metabolic thromboinflammatory axis.European journal of medical research · 2026Review
- sc-eQTL unveil immunogenetic architecture of polycystic ovary syndrome.Scientific reports · 2026Article
- Natural killer cell dysregulation in polycystic ovary syndrome: immunometabolic and reproductive implication.Frontiers in immunology · 2026Review
- Sheep placental extract ameliorates polycystic ovary syndrome in rats by regulating ERβ-mediated Treg cells via the TGF-β1/Smad3 signaling pathway.Frontiers in immunology · 2026Article
- Metabolic profiling of a polycystic ovary syndrome-like organoid model reveals the critical role of glutamine in local endometrial dysregulation related to implantation failure.Frontiers in cell and developmental biology · 2026Article
- Reduced mean platelet volume (MPV) as an inflammatory marker in Chinese women with polycystic ovary syndrome: a case-control study.BMC women's health · 2025Article
- Fundamental mechanisms of cell death for polycystic ovary syndrome.Biochemistry and biophysics reports · 2025Review
- Relationships between inflammatory indicators, nutritional status, and metabolic status and female infertility.Reproductive health · 2025Article
- High-dimensional immune profiling of follicular fluid and systemic circulation reveals distinct immune signatures in women with polycystic ovary syndrome.Frontiers in immunology · 2025Article
- Mendelian Randomization and Transcriptomics Analysis Reveal Potential Relationships Between Lipids, Immune Cells and PCOS.International journal of women's health · 2025Article
- Article
- Polycystic ovary syndrome.Nature reviews. Disease primers · 2024Review
- Expression profile analysis of LncRNAs and mRNAs in pre-receptive endometrium of women with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer.BMC medical genomics · 2024Article
- Implantation and Decidualization in PCOS: Unraveling the Complexities of Pregnancy.International journal of molecular sciences · 2024Review
- Inflammatory markers are associated with infertility prevalence: a cross-sectional analysis of the NHANES 2013-2020.BMC public health · 2024Article
- Transcriptomic analysis identifies diagnostic genes in polycystic ovary syndrome and periodontitis.European journal of medical research · 2024Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to investigate the inflammatory-immune cells in the peripheral blood of women with polycystic ovary syndrome (PCOS) and assessed the potential correlation between inflammatory-immune cells and infertility in PCOS women. MATERIALS AND
methodsIn this case-control study, the profiles of lymphocyte subsets were analyzed by flow cytometry. White blood cells (WBC), neutrophils (Neu), lymphocytes, Ferriman-Gallwey (F-G) score, testosterone, prolactin, follicle-stimulating hormone, luteinizing hormone, fasting blood glucose, and fasting plasma insulin were measured, together with body mass index. Association between inflammatory-immune cells and PCOS was evaluated. Moreover, inflammatory-immune cells of the PCOS women with infertility were evaluated, and the relative operating characteristic (ROC) curve and cutoff values were calculated.
resultsThe number of WBC, Neu, and lymphocytes was higher in PCOS women than controls (P<0.05). The percentages of total T lymphocytes, CD4+T, and NK were significantly increased in the PCOS group (P<0.001). The CD4/CD8 ratio was obviously elevated for increasing CD4+T (P<0.05). Consequently, T%, CD4+T%, and NK% were found to be the independent risk factors of PCOS by ROC curve and multivariate logistic regression analysis. Furthermore, only NK% was significantly higher in PCOS women with infertility than those who had PCOS without infertility (P<0.001). To diagnose infertility in PCOS, the cutoff value of NK% was calculated as 16.43%.
conclusionThese findings suggest that the pathogenesis of PCOS is related to immune cells including T, CD4+T, and NK cells. NK cells are likely to be a potential predictive factor for PCOS women with infertility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.