ArticleInternational journal of nanomedicine2020
Graphene Oxide Negatively Regulates Cell Cycle in Embryonic Fibroblast Cells.
Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Selenium-modified graphene oxide: A tri-dimensional study of its cytotoxicity and developmental effects.Materials today. Bio · 2026Article
- Functionalized chitosan-graphene magnetic nanocomposites enhance collagen synthesis in scleral fibroblasts.Open life sciences · 2026Article
- N-Doped Graphene for Biomedical Applications: A Comparative Biocompatibility Assessment of Green and Chemical Exfoliation.Chemical research in toxicology · 2025Article
- Exposure to nanoscale graphene oxide deteriorates the quality of porcine oocytes via induction of oxidative stress and the apoptosis.Journal of assisted reproduction and genetics · 2025Article
- Surface-tailored graphene nanosheets targeting PI3K/Akt signaling of breast cancer cells.Scientific reports · 2025Article
- Glucocorticoid-Mediated Extracellular Matrix Regulation: Implications for Precision Therapy.Biomedicines · 2025Review
- Radiosensitizing properties of dual-functionalized carbon nanostructures loaded with temozolomide.Beilstein journal of nanotechnology · 2025Article
- Preparation and characterization of calcium-doped graphene oxide-chitosan Nanocarrier to enhance the gene delivery in MCF-7 cell line.Scientific reports · 2024Article
- Graphene oxide and oxidized carbon nanodiscs as biomedical scaffolds for the targeted delivery of quercetin to cancer cells.Nanoscale advances · 2024Article
- Graphene-Related Nanomaterials for Biomedical Applications.Nanomaterials (Basel, Switzerland) · 2023Review
- Insights of Platinum Drug Interaction with Spinel Magnetic Nanocomposites for Targeted Anti-Cancer Effect.Cancers · 2023Article
- Graphene-based nanomaterials for peripheral nerve regeneration.Frontiers in bioengineering and biotechnology · 2023Review
- Implications of graphene-based materials in dentistry: present and future.Frontiers in chemistry · 2023Review
- The Reduced Graphene Oxide (rGO) Induces Apoptosis, Autophagy and Cell Cycle Arrest in Breast Cancer Cells.International journal of molecular sciences · 2022Article
- Genotoxicity of Graphene-Based Materials.Nanomaterials (Basel, Switzerland) · 2022Review
- PLATOX: Integrated In Vitro/In Vivo Approach for Screening of Adverse Lung Effects of Graphene-Related 2D Nanomaterials.Nanomaterials (Basel, Switzerland) · 2022Article
- Impact of Graphene Derivatives as Artificial Extracellular Matrices on Mesenchymal Stem Cells.Molecules (Basel, Switzerland) · 2022Review
- Graphene-Based Nanomaterials for Dental Applications: Principles, Current Advances, and Future Outlook.Frontiers in bioengineering and biotechnology · 2022Review
- Direct and Indirect Genotoxicity of Graphene Family Nanomaterials on DNA-A Review.Nanomaterials (Basel, Switzerland) · 2021Review
- Nano-Graphene Oxide-Promoted Epithelial-Mesenchymal Transition of Human Retinal Pigment Epithelial Cells through Regulation of Phospholipase D Signaling.Nanomaterials (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUnique properties of graphene and its derivatives make them attractive in the field of nanomedicine. However, the mass application of graphene might lead to side effects, which has not been properly addressed in previous studies, especially with regard to its effect on the cell cycle.
methodsThe effect of two concentrations (100 and 200 μg/mL) of nano- and microsized graphene oxide (nGO and mGO) on apoptosis, cell cycle, and ROS generation was studied. The effect of both sizes on viability and genotoxicity of the embryonic fibroblast cell cycle was evaluated. MTT and flow cytometry were applied to evaluate the effects of graphene oxide (GO) nanosheets on viability of cells. Apoptosis and cell cycle were analyzed by flow cytometry.
resultsThe results of this study showed that GO disturbed the cell cycle and nGO impaired cell viability by inducing cell apoptosis. Interestingly, both nGO and mGO blocked the cell cycle in the S phase, which is a critical phase of the cell cycle. Upregulation of
conclusionIn conclusion, graphene oxide at both nano- and micro-scale damages cell physiology and increases cell population in the S phase of the cell cycle.
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