Evidence map›Paper›PMID 32884250›Full record

ArticleClinical interventions in aging2020

Attenuated Renal and Hepatic Cells Apoptosis Following Swimming Exercise Supplemented with Garlic Extract in Old Rats.

Parvin Farzanegi, Hajar Abbaszadeh, Farzaneh Farokhi, Saleh Rahmati-Ahmadabad, Seyed Ali Hosseini, Abdi Ahmad, Mohammad Reza Mazandarani, Iraj Rezaei, Mohammad Shokrie, Exir Vizvari and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical interventions in aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Parvin FarzanegiDepartment of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran.
Hajar AbbaszadehDepartment of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran.
Farzaneh FarokhiDepartment of Biology, Faculty of Basic Sciences, Sari Branch, Islamic Azad University, Sari, Iran.
Saleh Rahmati-AhmadabadDepartment of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran.ORCID 0000-0001-8751-1759
Seyed Ali HosseiniDepartment of Sport Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran.
Abdi AhmadDepartment of Physical Education, Faculty of Physical Education, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.ORCID 0000-0002-7734-7518
Mohammad Reza MazandaraniDepartment of Physical Education, Farhangian University, Gorgan, Iran.
Iraj RezaeiDepartment of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran.
Mohammad ShokrieDepartment of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran.
Exir VizvariDepartment of Exercise Physiology, Faculty of Humanities, Shams Institute of Higher Education, Gonbad Kavous, Iran.
Hadi AlinejadDepartment of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran.
Mohammad Ali AzarbayjaniDepartment of Exercise Physiology, Islamic Azad University, Central Tehran Branch, Tehran, Iran.ORCID 0000-0002-3502-7487
Islamic Azad University Sari Branch · IRFarhangian University · IRGonbad Kavous University · IRIslamic Azad University Central Tehran Branch · IRIslamic Azad University, Marvdasht · IRIslamic Azad University of Ayatollah Amoli · IRIslamic Azad University, Tehran · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectiveOne of the problems associated with aging is the development of apoptosis in different tissues. There is evidence that physical activity and herbal remedies can be useful. This study aimed to determine the effect of swimming training (SW) alone or combined with garlic extract on renal and hepatic cells apoptosis, as wellas on the liver and kidney function biomarkers in old rats.

methodsA total of 35 old rats (aged 40-50 weeks) were randomly divided into 5 groups including control, saline (S), exercise training (ET), garlic (G) and exercise training+ garlic (ET.G) groups. Exercise was started for 5 min/day and then gradually extended to 60 min/day and the G and E+G groups received 1 mL/kg of this mixture by gavage. Twenty-four hours after completion of 8 weeks training, liver, kidney and blood samples were collected for histopathological examinations, liver and kidney functions, oxidative stress and apoptosis biomarkers.

resultsThe tissue sections of the SW exercise, control and saline groups showed some mild histopathological changes in liver and kidney, while SW supplemented with garlic prevented these damages. The SW alone or supplemented with garlic significantly increased the Bcl-2 value and declined the BAX level in both liver and kidney (p<0.05). The activities of catalase (CAT) and superoxide dismutase (SOD) in the liver and kidney of the control and saline groups were lower than those in E, G and G+E groups, while a significant increase for malondialdehyde (MDA) value was found in the control and saline groups. Furthermore, the E+G significantly declined the activity of hepatic (ALT, AST and ALP) and renal damage (uric acid, urea and creatinine) biomarkers compared to the control and saline groups (p<0.05). DISCUSSION: Swimming exercise supplemented with garlic extract not only improves antioxidant capacity but also declines oxidative damages and apoptosis through reducing Bax levels and enhancing Bcl-2 value.

Indexed as

ApoptosisAdaptor Proteins, Signal TransducingAnimalsAntioxidantsbcl-2-Associated X ProteinBiomarkersDietary SupplementsGarlicKidneyLiverOxidative StressPhysical Conditioning, AnimalPlant ExtractsRatsSwimmingTreatment OutcomeAdaptor Proteins, Signal TransducingAntioxidantsbcl-2-Associated X ProteinBiomarkersPlant Extractsantioxidantapoptosisgarlic extractold ratsoxidative stressswimming exercise

Identifiers

PMID32884250
PMCPMC7443438
OpenAlexW3049507421

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.