Evidence map›Paper›PMID 32884248›Full record

ArticleClinical interventions in aging2020

Human Adipose Tissue-Derived Mesenchymal Stem Cells in Parkinson's Disease: Inhibition of T Helper 17 Cell Differentiation and Regulation of Immune Balance Towards a Regulatory T Cell Phenotype.

Yong Bi, Xiaobin Lin, Huazheng Liang, Dehao Yang, Xiaowei Zhang, Jianming Ke, Jingjing Xiao, Zhilin Chen, Weian Chen, Xu Zhang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical interventions in aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Yong BiDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.
Xiaobin LinDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Huazheng LiangDepartment of Neurology, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, People's Republic of China.ORCID 0000-0001-9097-7357
Dehao YangDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.ORCID 0000-0002-4129-9761
Xiaowei ZhangDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Jianming KeDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Jingjing XiaoDepartment of Neurology, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, People's Republic of China.ORCID 0000-0001-9915-0815
Zhilin ChenDepartment of Neurology, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, People's Republic of China.ORCID 0000-0003-4594-2731
Weian ChenDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Xu ZhangDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Shaoshi WangDepartment of Neurology, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, People's Republic of China.
Chun-Feng LiuDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.ORCID 0000-0003-1436-4422
Wenzhou Medical University · CNTongji University · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParkinson's disease (PD) is a neurodegenerative disorder displaying a typical neuroinflammation pathology that may result from an imbalance between regulatory T cells (Treg) and T helper 17 (Th17) cells. Human adipose tissue-derived mesenchymal stem cells (Ad-MSCs) exert immunomodulatory effects by inhibiting effector T cell responses and have been used to treat diverse immune disorders. We aimed to investigate the modulating effect of human Ad-MSCs on peripheral blood mononuclear cells (PBMCs) of patients with PD, focusing on differentiation into Th17 and Treg cells.

methodsWe isolated human peripheral blood CD4

resultsOur results showed that Ad-MSCs specifically inhibited the differentiation of PBMCs of patients with PD into IL-17-producing CD4

conclusionThe present in vitro study found that Ad-MSCs from healthy participants were able to correct the imbalance between Th17 and Treg found in PBMCs of PD patients, which were correlated with an increase in LIF secretion and a decrease in expression of IL-6R, IL-23R, and RORγt. These findings should be confirmed by in vivo experiments.

Indexed as

Th17 CellsT-Lymphocytes, RegulatoryCell DifferentiationCells, CulturedHumansInterleukin-10Interleukin-2 Receptor alpha SubunitLeukemia Inhibitory FactorLeukocytes, MononuclearMesenchymal Stem CellsNuclear Receptor Subfamily 1, Group F, Member 3Parkinson DiseasePhenotypeSignal TransductionIL10 protein, humanIL2RA protein, humanInterleukin-10Interleukin-2 Receptor alpha SubunitLeukemia Inhibitory FactorLIF protein, humanNuclear Receptor Subfamily 1, Group F, Member 3adipose-derived mesenchymal stem cellsCD4+T cellleukemia inhibitory factorParkinson’s diseaseperipheral blood mononuclear cellsT helper 17 cellT regulatory cell

Identifiers

PMID32884248
PMCPMC7434526
OpenAlexW3048672456

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.