ArticleThe ISME journal2021
To hunt or to rest: prey depletion induces a novel starvation survival strategy in bacterial predators.
Article in The ISME journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Predation in microbial communities: gradients of nutritive killing.Nature reviews. Microbiology · 2026Review
- Article
- Article
- Bdellovibrio's prey-independent lifestyle is fueled by amino acids as a carbon source.Applied microbiology and biotechnology · 2024Article
- Controlling the expression of heterologous genes in Bdellovibrio bacteriovorus using synthetic biology strategies.Microbial biotechnology · 2024Article
- Ecological relevance of flagellar motility in soil bacterial communities.The ISME journal · 2024Article
- Disentangling the Ecological Processes and Driving Forces Shaping the Seasonal Pattern of Halobacteriovorax Communities in a Subtropical Estuary.Microbial ecology · 2023Article
- Two-state swimming: Strategy and survival of a model bacterial predator in response to environmental cues.Biophysical journal · 2023Article
- Moving toward a better understanding of the model bacterial predatorMicrobiology (Reading, England) · 2023Article
- Self-demise of soft rot bacteria by activation of microbial predators by pectin-based carriers.Microbial biotechnology · 2023Article
- Parallel Evolution in PredatoryApplied and environmental microbiology · 2023Article
- Advances in cellular and molecular predatory biology ofFrontiers in microbiology · 2023Review
- A Comparative Study of the Dynamics and Diversity ofMicroorganisms · 2022Article
- The ecological roles of bacterial chemotaxis.Nature reviews. Microbiology · 2022Review
- Community and single cell analyses reveal complex predatory interactions between bacteria in high diversity systems.Nature communications · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The small size of bacterial cells necessitates rapid adaption to sudden environmental changes. In Bdellovibrio bacteriovorus, an obligate predator of bacteria common in oligotrophic environments, the non-replicative, highly motile attack phase (AP) cell must invade a prey to ensure replication. AP cells swim fast and respire at high rates, rapidly consuming their own contents. How the predator survives in the absence of prey is unknown. We show that starvation for prey significantly alters swimming patterns and causes exponential decay in prey-searching cells over hours, until population-wide swim-arrest. Swim-arrest is accompanied by changes in energy metabolism, enabling rapid swim-reactivation upon introduction of prey or nutrients, and a sweeping change in gene expression and gene regulation that largely differs from those of the paradigmatic stationary phase. Swim-arrest is costly as it imposes a fitness penalty in the form of delayed growth. We track the control of the swim arrest-reactivation process to cyclic-di-GMP (CdG) effectors, including two motility brakes. CRISPRi transcriptional inactivation, and in situ localization of the brakes to the cell pole, demonstrated their essential role for effective survival under prey-induced starvation. Thus, obligate predators evolved a unique CdG-controlled survival strategy, enabling them to sustain their uncommon lifestyle under fluctuating prey supply.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.