ArticleScientific reports2020
Metabolic response of the Siberian wood frog Rana amurensis to extreme hypoxia.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
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- Ecometabolomics reveal physiological adaptations of Asiatic toads (Bufo gargarizans Cantor, 1842) to different environments along an altitudinal gradient.Frontiers in zoology · 2025Article
- Metabolic stability of the Pallas' spadefoot Pelobates vespertinus under extreme hypoxia.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- Proteomic analysis of Rana sylvatica reveals differentially expressed proteins in liver in response to anoxia, dehydration or freezing stress.Scientific reports · 2024Article
- Validation of Salamander Dermal Mucus Swabs as a Novel, Nonlethal Approach for Amphibian Metabolomics and Glutathione Analysis Following Pesticide Exposure.Environmental toxicology and chemistry · 2024Article
- Comparative metabolomics analysis reveals high-altitude adaptations in a toad-headed viviparous lizard, Phrynocephalus vlangalii.Frontiers in zoology · 2023Article
- Metabolomic Profiling Reveals Differences in Hypoxia Response between Far Eastern and Siberian Frogs.Animals : an open access journal from MDPI · 2023Article
- Animal Metabolite Database: Metabolite Concentrations in Animal Tissues and Convenient Comparison of Quantitative Metabolomic Data.Metabolites · 2023Article
- Biochemical response of two earthworm taxa exposed to freezing.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023Article
- A comparative metabolomics analysis of domestic yak (Frontiers in veterinary science · 2023Article
- Resilience and phenotypic plasticity of Arctic char (Conservation physiology · 2023Article
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- Urinary metabolic modulation in human participants residing in Siachen: a 1H NMR metabolomics approach.Scientific reports · 2022Article
- Metabolomic Analysis Reveals That the Moor FrogAnimals : an open access journal from MDPI · 2022Article
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- Hypoxia Tolerant Species: The Wisdom of Nature Translated into Targets for Stroke Therapy.International journal of molecular sciences · 2021Review
- The Metabolomic Response of Crucian Carp (Metabolites · 2021Article
- Metabolomics improves the histopathological diagnosis of asphyxial deaths: an animal proof-of-concept model.Scientific reports · 2021Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Siberian wood frog Rana amurensis is a recently discovered example of extreme hypoxia tolerance that is able to survive several months without oxygen. We studied metabolomic profiles of heart and liver of R. amurensis exposed to 17 days of extreme hypoxia. Without oxygen, the studied tissues experience considerable stress with a drastic decrease of ATP, phosphocreatine, and NAD+ concentrations, and concomitant increase of AMP, creatine, and NADH. Heart and liver switch to different pathways of glycolysis with differential accumulation of lactate, alanine, succinate, as well as 2,3-butanediol (previously not reported for vertebrates as an end product of glycolysis) and depletion of aspartate. We also observed statistically significant changes in concentrations of certain osmolytes and choline-related compounds. Low succinate/fumarate ratio and high glutathione levels indicate adaptations to reoxygenation stress. Our data suggest that maintenance of the ATP/ADP pool is not required for survival of R. amurensis, in contrast to anoxia-tolerant turtles.
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