ArticleScientific reports2020
Comprehensive profiling of Asian and Caucasian meibomian gland secretions reveals similar lipidomic signatures regardless of ethnicity.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Tear function in patients with diabetes mellitus: A systematic review and meta-analysis.Frontiers in endocrinology · 2022Pooled it
- Intracrine androgen metabolism in the meibomian gland: regulation, circadian control, and implications in dry eye disease.Endocrine journal · 2026Review
- Direct Correlation of Levels of Meibum Cholesteryl Esters, Hydrocarbon Chain Saturation, and Protein With Lipid Structure, in Relation to Age and Dry Eye.Investigative ophthalmology & visual science · 2026Article
- Composition of Human Meibomian Gland Secretions: Insights from TOF-SIMS Analysis.International journal of molecular sciences · 2026Article
- Comprehensive Analysis of the Conjunctival Sac Microbiome in Patients With Evaporative Dry Eye and Mixed Dry Eye.Translational vision science & technology · 2026Article
- Identification of meibomian gland testosterone metabolites produced by tissue-intrinsic intracrine deactivation activity.iScience · 2025Article
- Long-Term Evaluation of Ocular Surface and Meibomian Gland Function after Laser-Assisted in situ Keratomileusis Surgery.Ophthalmic research · 2025Article
- Dysregulation of Lipid Metabolism in Aging Meibomian Glands and Its Molecular Markers.International journal of molecular sciences · 2023Article
- Relationship Between Human Meibum Lipid Composition and the Severity of Meibomian Gland Dysfunction: A Spectroscopic Analysis.Investigative ophthalmology & visual science · 2023Article
- Induction of meibocyte differentiation by three-dimensional, matrigel culture of immortalized human meibomian gland epithelial cells to form acinar organoids.The ocular surface · 2022Article
- Dynamic Changes in the Gene Expression Patterns and Lipid Profiles in the Developing and Maturing Meibomian Glands.International journal of molecular sciences · 2022Article
- Novel Lipids of the Rabbit Harderian Gland Improve Tear Stability in an Animal Model of Dry Eye Disease.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2021Article
- Effects of Aging on Human Meibum.Investigative ophthalmology & visual science · 2021Article
- A spectroscopic study of the composition and conformation of cholesteryl and wax esters purified from meibum.Chemistry and physics of lipids · 2021Article
- Differential effects of dietary cholesterol and triglycerides on the lipid homeostasis in Meibomian glands.The Journal of steroid biochemistry and molecular biology · 2021Article
- Depletion of Cholesteryl Esters Causes Meibomian Gland Dysfunction-Like Symptoms in aInternational journal of molecular sciences · 2021Article
- Meibomian gland development: Where, when and how?Differentiation; research in biological diversityReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Meibum-a lipid secretion that is produced by Meibomian glands (MG) in a process termed meibogenesis-plays a critical role in ocular surface physiology. Abnormalities in the chemical composition of meibum were linked to widespread ocular pathologies-dry eye syndrome (DES) and MG dysfunction (MGD). Importantly, in epidemiologic studies the Asian population was shown to be prone to these pathologies more than the Caucasian one, which was tied to differences in their meibomian lipids. However, biochemical data to support these observations and conclusions are limited. To determine if non-DES/non-MGD Asian meibum was significantly different from that of Caucasians, individual samples of meibum collected from ethnic Asian population living in Japan were compared with those of Caucasians living in the USA. These experiments revealed that composition of major lipid classes, such as wax esters (WE), cholesteryl esters (CE), triacylglycerols, (O)-acylated ω-hydroxy fatty acids (OAHFA), cholesteryl sulfate, cholesteryl esters of OAHFA, and diacylated α,ω-dihydroxy fatty alcohols remained invariable in both races, barring a minor (< 10%; p < 0.01) increase in the Asian CE/WE ratio. Considering the natural variability range for most meibomian lipids (app. ± 15% of the Mean), these differences in meibogenesis were deemed to be minimal and unlikely to have a measurable physiological impact.
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