Evidence map›Paper›PMID 32883962›Full record

ArticleScientific reports2020

MicroRNA-107 enhances radiosensitivity by suppressing granulin in PC-3 prostate cancer cells.

Hua-Cheng Lo, Jia-Hao Hsu, Liang-Chuan Lai, Mong-Hsun Tsai, Eric Y Chuang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hua-Cheng LoDivision of Urological Surgery, Department of Surgery, Tri-Service General Hospital Songshan Branch, National Defense Medical Center, Taipei, 10581, Taiwan, ROC.ORCID http://orcid.org/0000-0002-8396-8038
Jia-Hao HsuDivision of Urological Surgery, Department of Surgery, Tri-Service General Hospital Songshan Branch, National Defense Medical Center, Taipei, 10581, Taiwan, ROC.
Liang-Chuan LaiGraduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei, 100, Taiwan, ROC.ORCID http://orcid.org/0000-0002-3913-5338
Mong-Hsun TsaiBioinformatics and Biostatistics Core, Center of Genomic and Precision Medicine, National Taiwan University, Taipei, 10055, Taiwan, ROC.
Eric Y ChuangGraduate Institute of Biomedical Electronics and Bioinformatics, Department of Electrical Engineering, National Taiwan University, Taipei, 10617, Taiwan, ROC. chuangey@ntu.edu.tw.
National Taiwan University · TW

Funding

MECHANISMS FOR RNA SPLICING IN CELLULAR ORGANELLESF32GM010803 · NIGMS · UNIVERSITY OF ARIZONA · PI REARDON, ELLEN M · 1985 to 1987
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6 · The paper itself

Abstract

Prostate cancer is the second leading cause of cancer-related death worldwide. Radiotherapy is often applied for the treatment, but radioresistance is a challenge in some patients. MicroRNAs have been reported to be involved in the DNA damage response induced by ionizing radiation and recent studies have reported microRNA-mediated radiosensitivity. In the present study, we found microRNA-107 (miR-107) enhanced radiosensitivity by regulating granulin (GRN) in prostate cancer (PC-3) cells. MiR-107 was downregulated and GRN was upregulated in response to ionizing radiation in PC-3 cells. Overexpression of miR-107 and knockdown of GRN promoted the sensitivity of PC3 cells to ionizing radiation. By rescue experiments of GRN, we revealed that radiosensitivity enhanced by miR-107 can be attenuated by GRN overexpression in PC-3 cells. Furthermore, we showed miR-107 enhanced radiation-induced G1/S phase arrest and G2/M phase transit, and identify delayed apoptosis by suppressing p21 and phosphorylation of CHK2. Collectively, these results highlight an unrecognized mechanism of miR-107-mediated GRN regulation in response to ionizing radiation and may advance therapeutic strategies for the treatment of prostate cancer.

Indexed as

Gene Expression Regulation, NeoplasticRadiation, IonizingApoptosisBiomarkers, TumorCell ProliferationHumansMaleMicroRNAsProgranulinsProstatic NeoplasmsRadiation ToleranceTumor Cells, CulturedBiomarkers, TumorGRN protein, humanMicroRNAsMIRN107 microRNA, humanProgranulins

Identifiers

PMID32883962
PMCPMC7471693
OpenAlexW3082203085

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.