ArticleProceedings of the National Academy of Sciences of the United States of America2020
Scaling relationships for the elastic moduli and viscosity of mixed lipid membranes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 81 citations in OpenAlex.
- Structural Remodeling of Mitochondrial Membranes in Cancerous Colon Cells: Insights from Neutron Scattering and Lipidomics.ACS bio & med chem Au · 2026Article
- Lipid Saturation and Cholesterol Drive the Mechanical Response of Lipid Bilayer to Ionic Liquid: An Atomic Force Microscopy Study.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- Development of Transferable Coarse-Grained Lipid Models with Optimized Structural and Elastic Membrane Properties.Journal of chemical theory and computation · 2025Article
- Asymmetric membrane properties through a protein lens.Faraday discussions · 2025Article
- Kinetics of light-induced mesophase transitions in azo-benzene amphiphiles containing lyotropic liquid crystals.Journal of applied crystallography · 2025Article
- Cholesterol modulates membrane elasticity via unified biophysical laws.Nature communications · 2025Article
- "Head-to-Toe" Lipid Properties Govern the Binding and Cargo Transfer of High-Density Lipoprotein.Membranes · 2024Article
- Curvature fluctuations of fluid vesicles reveal hydrodynamic dissipation within the bilayer.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Neutron spin echo shows pHLIP is capable of retarding membrane thickness fluctuations.Biochimica et biophysica acta. Biomembranes · 2024Article
- Synergistic effects of oxidative and acid stress on bacterial membranes of Escherichia coli and Staphylococcus simulans.Communications biology · 2024Article
- Rotation of the c-Ring Promotes the Curvature Sorting of Monomeric ATP Synthases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Mechanical Responses of a Single Myelin Layer: A Molecular Simulation Study.Biomolecules · 2023Article
- Revealing the Impacts of Chemical Complexity on Submicrometer Sea Spray Aerosol Morphology.ACS central science · 2023Article
- Neutron scattering studies on dynamics of lipid membranes.Biophysics reviews · 2023Review
- Compressible viscoelasticity of cell membranes determined by gigahertz-frequency acoustic vibrations.Photoacoustics · 2023Article
- Molecular simulations and NMR reveal how lipid fluctuations affect membrane mechanics.Biophysical journal · 2023Article
- Capturing Lipid Nanodisc Shape and Properties Using a Continuum Elastic Theory.Journal of chemical theory and computation · 2023Article
- Membrane free-energy landscapes derived from atomistic dynamics explain nonuniversal cholesterol-induced stiffening.bioRxiv : the preprint server for biology · 2023Article
- Biophysics of Membrane Stiffening by Cholesterol and Phosphatidylinositol 4,5-bisphosphate (PIP2).Advances in experimental medicine and biology · 2023Article
- Small-Angle Neutron Scattering for Studying Lipid Bilayer Membranes.Biomolecules · 2022Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The elastic and viscous properties of biological membranes play a vital role in controlling cell functions that require local reorganization of the membrane components as well as dramatic shape changes such as endocytosis, vesicular trafficking, and cell division. These properties are widely acknowledged to depend on the unique composition of lipids within the membrane, yet the effects of lipid mixing on the membrane biophysical properties remain poorly understood. Here, we present a comprehensive characterization of the structural, elastic, and viscous properties of fluid membranes composed of binary mixtures of lipids with different tail lengths. We show that the mixed lipid membrane properties are not simply additive quantities of the single-component analogs. Instead, the mixed membranes are more dynamic than either of their constituents, quantified as a decrease in their bending modulus, area compressibility modulus, and viscosity. While the enhanced dynamics are seemingly unexpected, we show that the measured moduli and viscosity for both the mixed and single-component bilayers all scale with the area per lipid and collapse onto respective master curves. This scaling links the increase in dynamics to mixing-induced changes in the lipid packing and membrane structure. More importantly, the results show that the membrane properties can be manipulated through lipid composition the same way bimodal blends of surfactants, liquid crystals, and polymers are used to engineer the mechanical properties of soft materials, with broad implications for understanding how lipid diversity relates to biomembrane function.
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