Evidence map›Paper›PMID 32883834›Full record

ArticleScience (New York, N.Y.)2020

Changes in regeneration-responsive enhancers shape regenerative capacities in vertebrates.

Wei Wang, Chi-Kuo Hu, An Zeng, Dana Alegre, Deqing Hu, Kirsten Gotting, Augusto Ortega Granillo, Yongfu Wang, Sofia Robb, Robert Schnittker and 7 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

134 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Killiverse: an interactive multi-omics web resource for killifish.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Signal control during tissue regeneration in adult animals.Nature reviews. Molecular cell biology · 2026
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Conversion of Transplanted Mature Hepatocytes into AfpAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  18. Article
  19. Article
  20. Review

74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Wei WangStowers Institute for Medical Research, Kansas City, MO 64110, USA.ORCID 0000-0001-9511-3611
Chi-Kuo HuDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-9773-972X
An ZengStowers Institute for Medical Research, Kansas City, MO 64110, USA.ORCID 0000-0003-3011-5709
Dana AlegreStowers Institute for Medical Research, Kansas City, MO 64110, USA.
Deqing HuStowers Institute for Medical Research, Kansas City, MO 64110, USA.ORCID 0000-0002-8929-0651
Kirsten GottingStowers Institute for Medical Research, Kansas City, MO 64110, USA.ORCID 0000-0003-3492-1097
Augusto Ortega GranilloStowers Institute for Medical Research, Kansas City, MO 64110, USA.ORCID 0000-0001-9954-4697
Yongfu WangStowers Institute for Medical Research, Kansas City, MO 64110, USA.ORCID 0000-0003-3499-0586
Sofia RobbStowers Institute for Medical Research, Kansas City, MO 64110, USA.ORCID 0000-0002-3528-5267
Robert SchnittkerStowers Institute for Medical Research, Kansas City, MO 64110, USA.ORCID 0000-0002-2950-8604
Shasha ZhangStowers Institute for Medical Research, Kansas City, MO 64110, USA.
Dillon AlegreStowers Institute for Medical Research, Kansas City, MO 64110, USA.
Hua LiStowers Institute for Medical Research, Kansas City, MO 64110, USA.
Eric RossStowers Institute for Medical Research, Kansas City, MO 64110, USA.ORCID 0000-0001-8317-7271
Ning ZhangStowers Institute for Medical Research, Kansas City, MO 64110, USA.ORCID 0000-0001-6643-6980
Anne BrunetDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-4608-6845
Alejandro Sánchez AlvaradoStowers Institute for Medical Research, Kansas City, MO 64110, USA. asa@stowers.org.ORCID 0000-0002-1966-6959

Funding

Transgenerational epigenetic inheritance of longevityDP1AG044848 · NIA · STANFORD UNIVERSITY · PI BRUNET, ANNE · 2012 to 2016
$3.9M
The molecular basis of planarian regenerationR37GM057260 · NIGMS · UNIVERSITY OF UTAH · PI SANCHEZ ALVARADO, ALEJANDRO · 2009 to 2018
$2.8M
Howard Hughes Medical InstituteNIA NIH HHS DP1 AG044848NIGMS NIH HHS R37 GM057260
6 · The paper itself

Abstract

Vertebrates vary in their ability to regenerate, and the genetic mechanisms underlying such disparity remain elusive. Comparative epigenomic profiling and single-cell sequencing of two related teleost fish uncovered species-specific and evolutionarily conserved genomic responses to regeneration. The conserved response revealed several regeneration-responsive enhancers (RREs), including an element upstream to

Indexed as

Evolution, MolecularAmino Acid MotifsAnimalsEnhancer Elements, GeneticEpigenesis, GeneticGene Expression ProfilingHistonesInhibin-beta SubunitsKillifishesRegenerationRNA-SeqSingle-Cell AnalysisTranscriptional ActivationTranscription Factor AP-1ZebrafishHistonesinhibin beta A subunitInhibin-beta SubunitsTranscription Factor AP-1

Identifiers

PMID32883834
PMCPMC9479427

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.