ArticleThe Journal of biological chemistry2020
Actin-binding protein profilin1 promotes aggressiveness of clear-cell renal cell carcinoma cells.
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Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Profilin-1 Deficiency Activates STING to Drive T Cell-Mediated Anti-Tumor Immunity in Breast Cancer.bioRxiv : the preprint server for biology · 2026Article
- Profilin-1 Promotes Chromophobe Renal Cell Carcinoma Malignancy.bioRxiv : the preprint server for biology · 2026Article
- Profillin-1 and Transgelin-2: Actin Binding Proteins Expression in Early and Advanced Stages of Triple-Negative Breast Cancer Receiving Neoadjuvant Chemotherapy.Cancer reports (Hoboken, N.J.) · 2026Article
- Lysophosphatidylethanolamine 18:1 drives clear cell renal cell carcinoma by stabilizing SIRT6 to reprogram lipid metabolism.Signal transduction and targeted therapy · 2025Article
- Small molecule intervention of actin-binding protein profilin1 reduces tumor angiogenesis in renal cell carcinoma.bioRxiv : the preprint server for biology · 2025Article
- Extracellular Vesicles Carrying Tenascin-C are Clinical Biomarkers and Improve Tumor-Derived DNA Analysis in Glioblastoma Patients.ACS nano · 2025Article
- Gastrodin Mitigates Ketamine-Induced Inhibition of F-Actin Remodeling and Cell Migration by Regulating the Rho Signaling Pathway.Biomedicines · 2025Article
- Exploring Molecular Alterations in Breast Cancer Among Indian Women Using Label-Free Quantitative Serum Proteomics.Biochemistry research international · 2024Article
- Profilin1 is required for prevention of mitotic catastrophe in murine and human glomerular diseases.The Journal of clinical investigation · 2023Article
- Vascular endothelial cell-specific disruption of thePNAS nexus · 2023Article
- BAL Proteomic Signature of Lung Adenocarcinoma in IPF Patients and Its Transposition in Serum Samples for Less Invasive Diagnostic Procedures.International journal of molecular sciences · 2023Article
- The intrarenal landscape of T cell receptor repertoire in clear cell renal cell cancer.Journal of translational medicine · 2022Article
- Bioinformatics analysis of KLF2 as a potential prognostic factor in ccRCC and association with epithelial-mesenchymal transition.Experimental and therapeutic medicine · 2022Article
- From Basic Science to Clinical Translation in Kidney Cancer: A Report from the Second Kidney Cancer Research Summit.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022Article
- Inhibition of ocular neovascularization by novel anti-angiogenic compound.Experimental eye research · 2021Article
- Article
- The role of profilin-1 in cardiovascular diseases.Journal of cell science · 2021Review
- Article
- Clinical and Morphological Study of Cervical Squamous Intraepithelial Lesions.Current health sciences journalArticle
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 2 countries.
Abigail AllenDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
David GauDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Paul FrancoeurDepartment of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jordan SturmDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Yue WangDepartment of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Ryan MartinDepartment of Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jodi MaranchieDepartment of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Anette DuensingDepartment of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Adam KaczorowskiDepartment of Urology, Heidelberg School of Medicine, Heidelberg, Germany.
Stefan DuensingDepartment of Urology, Heidelberg School of Medicine, Heidelberg, Germany.
Lily WuDepartment of Urology, University of California, Los Angeles, Los Angeles, California, USA.
Michael T LotzeDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania USA.
David KoesDepartment of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Walter J StorkusDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania USA; Department of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania USA.
Partha RoyDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address: Partha.Roy@pitt.edu.
University of Pittsburgh · USHeidelberg University · DEUniversity of California, Los Angeles · US
Funding
Cardiovascular Bioengineering Training ProgramT32HL076124 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SANJEEV G SHROFF · 2005 to 2026
$7.0MTraining Program in Imaging Sciences in Translational Cardiovascular ResearchT32HL129964 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Flordeliza S Villanueva · 2016 to 2026
$4.7MProfilin as a target to suppress Invasive breast cancerR01CA108607 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROY, PARTHA · 2006 to 2017
$2.6M(PQ5) Mitochondria are endocellular symbionts that serve as targets for immune recognitionR01CA206012 · NCI · UNIVERSITY OF PENNSYLVANIA · PI FACCIABENE, ANDREA · 2016 to 2020
$2.0MMethods, Tools and Resources for Interactive Online Virtual Screening and Lead OptimizationR01GM108340 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOES, DAVID RYAN · 2013 to 2020
$1.8MPancreatic Ductal Adenocarcinoma is a disease of constitutive autophagyR01CA181450 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOTZE, MICHAEL T, ZEH, HERBERT J · 2014 to 2018
$1.6MNCI NIH HHS R01 CA108607NCI NIH HHS R01 CA181450NCI NIH HHS R01 CA206012NHLBI NIH HHS T32 HL076124NHLBI NIH HHS T32 HL129964NIGMS NIH HHS R01 GM108340
Abstract
Clear-cell renal cell carcinoma (ccRCC), the most common subtype of renal cancer, has a poor clinical outcome. A hallmark of ccRCC is genetic loss-of-function of
Indexed as
ActinsAnimalsCapZ Actin Capping ProteinCarcinoma, Renal CellCell Line, TumorCell MovementCell ProliferationCofilin 1Databases, GeneticEndothelial CellsHumansKidney NeoplasmsMiceMice, Inbred BALB CProfilinsPrognosisActinsCAPZA1 protein, humanCapZ Actin Capping ProteinCofilin 1PFN1 protein, humanProfilinsRNA, Small Interferingactinactin-binding proteinscancer biologyclear-cell renal cell carcinomaendothelial cellMenaprofilinProfilinrenal cancersmall molecule inhibitortumortumor-associated vascular endothelial cellsVASP
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.