ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Distinct Corticospinal and Reticulospinal Contributions to Voluntary Control of Elbow Flexor and Extensor Muscles in Humans with Tetraplegia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 59 citations in OpenAlex.
- Resistance training tempo selectively modulates corticospinal and reticulospinal excitability in humans.The Journal of physiology · 2026Trial
- Determining the cortical, corticospinal, and reticulospinal responses to metronome-paced and self-paced strength training.European journal of applied physiology · 2026Trial
- Intermittent theta burst stimulation modulates biceps brachii corticomotor excitability in individuals with tetraplegia.Journal of neuroengineering and rehabilitation · 2022Trial
- Descending Brainstem Systems Contribute to Ankle Clonus in Humans with Spinal Cord Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Impact of the brainstem in normal and impaired human movement control.The Journal of physiology · 2026Review
- Novel evidence of age-related cortical and subcortical constraints in cross-education.GeroScience · 2026Article
- Functional muscle networks as biomarkers of post-stroke motor impairment and therapeutic responsiveness.eLife · 2026Article
- Age-related differences in corticospinal and reticulospinal adaptations to short-term strength training.European journal of applied physiology · 2026Article
- Enhanced Reticulospinal Output in Subacute Spinal Cord Injury Patients with Spasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Non-invasive spinal cord neuromodulation enables volitional anti-gravity leg movements after motor-complete spinal cord injury: responders vs. non-responders.Journal of neuroengineering and rehabilitation · 2026Observational
- Evidence for Increased High Alpha Intermuscular Coherence as a Measure of Reticulospinal Motor Drive.The European journal of neuroscience · 2026Article
- Breathing-driven modulation of reticulospinal tract activity.Experimental physiology · 2026Article
- Transient effects in corticospinal and reticulospinal tract excitability induced by motor skill and isometric resistance training.Brain research · 2026Article
- Involvement of the reticulospinal tract in the pathogenesis of spasticity after stroke and spinal cord injury.Frontiers in neuroscience · 2026Review
- A narrative review of motor control dual pathways: the corticospinal and reticulospinal tracts in synergy and differentiation.Frontiers in neuroanatomy · 2026Review
- Cuneiform Nucleus Stimulation Can Assist Gait Training to Promote Locomotor Recovery in Individuals With Incomplete Tetraplegia.Annals of neurology · 2026Article
- Mapping reticulospinal drive across various muscles of the upper and lower extremities.Experimental physiology · 2025Article
- Differences in Hebbian stimulation effects between biceps and triceps brachii in humans.Journal of neurophysiology · 2025Article
- There Are No Differences in Startle Conditioned Cervicomedullary Motor Evoked Potentials Across Isometric, Concentric, and Eccentric Muscle Actions at the Same Absolute Force Output.The European journal of neuroscience · 2025Article
- Comparison of the reticulospinal drive to lumbar erector spinae muscles in postural and voluntary tasks using the StartReact paradigm.Frontiers in human neuroscience · 2025Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Humans with cervical spinal cord injury (SCI) often recover voluntary control of elbow flexors and, to a much lesser extent, elbow extensor muscles. The neural mechanisms underlying this asymmetrical recovery remain unknown. Anatomical and physiological evidence in animals and humans indicates that corticospinal and reticulospinal pathways differentially control elbow flexor and extensor motoneurons; therefore, it is possible that reorganization in these pathways contributes to the asymmetrical recovery of elbow muscles after SCI. To test this hypothesis, we examined motor-evoked potentials (MEPs) elicited by transcranial magnetic stimulation over the arm representation of the primary motor cortex, maximal voluntary contractions, the StartReact response (a shortening in reaction time evoked by a startling stimulus), and the effect of an acoustic startle cue on MEPs elicited by cervicomedullary stimulation (CMEPs) on biceps and triceps brachii in males and females with and without chronic cervical incomplete SCI. We found that SCI participants showed similar MEPs and maximal voluntary contractions in biceps but smaller responses in triceps compared with controls, suggesting reduced corticospinal inputs to elbow extensors. The StartReact and CMEP facilitation was larger in biceps but similar to controls in triceps, suggesting enhanced reticulospinal inputs to elbow flexors. These findings support the hypothesis that the recovery of biceps after cervical SCI results, at least in part, from increased reticulospinal inputs and that the lack of these extra inputs combined with the loss of corticospinal drive contribute to the pronounced weakness found in triceps.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.