Evidence map›Paper›PMID 32883245›Full record

ArticleBMC nephrology2020

Interventions Made to Preserve Cognitive Function Trial (IMPCT) study protocol: a multi-dialysis center 2x2 factorial randomized controlled trial of intradialytic cognitive and exercise training to preserve cognitive function.

Mara A McAdams-DeMarco, Nadia M Chu, Malu Steckel, Sneha Kunwar, Marlís González Fernández, Michelle C Carlson, Derek M Fine, Lawrence J Appel, Marie Diener-West, Dorry L Segev

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03616535 (Hemodialysis-based Interventions to Preserve Cognitive Function), which is not on this map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03616535 naterminatednot on this map

Hemodialysis-based Interventions to Preserve Cognitive Function

TypeinterventionalSponsorJohns Hopkins UniversityRan2018 to 2023Enrolled130ConditionsESRDArmsCognitive training, Exercise training, Combined cognitive and exercise training
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Exercise training for adults undergoing maintenance dialysis.The Cochrane database of systematic reviews · 2022
    Pooled it
  3. Trial
  4. Diagnosis and Management of Dementia for the Nephrology Clinician: A Review.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Mara A McAdams-DeMarcoDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA. mara@jhu.edu.ORCID 0000-0003-3013-925X
Nadia M ChuDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Malu SteckelDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sneha KunwarDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Marlís González FernándezDepartment of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michelle C CarlsonDepartment of Mental Health, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Derek M FineDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lawrence J AppelDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615, N. Wolfe St, W6033, Baltimore, MD, 21205, USA.
Marie Diener-WestDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Dorry L SegevDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · US

Funding

Hemodialysis-based interventions to preserve cognitive functionR01DK114074 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MCADAMS DEMARCO, MARA A. · 2018 to 2022
$3.9M
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
Frailty, Post-Transplant Delirium, and Neurocognitive Underpinnings of AlzheimersK01AG064040 · NIA · JOHNS HOPKINS UNIVERSITY · PI CHU, NADIA MIKHAIL · 2020 to 2022
$390k
NIA NIH HHS K01 AG064040NIDDK NIH HHS K24 DK101828NIDDK NIH HHS R01 DK114074
6 · The paper itself

Abstract

backgroundKidney disease and dialysis significantly impact cognitive function across the age spectrum. Cognitive training (CT) and/or exercise training (ET) are promising approaches to preserve cognitive function among community-dwelling older adults, but have not been tested for cognition preservation in hemodialysis patients of all ages. In this manuscript, we summarize the protocol for the Interventions Made to Preserve Cognitive Function Trial (IMPCT).

methodsWe will perform a 2 × 2 factorial randomized controlled trial (RCT) of eligible adult (≥18 years) hemodialysis initiates (n = 200) to test whether intradialytic CT (brain games on a tablet PC), ET (foot peddlers) and combined CT + ET while undergoing hemodialysis preserves executive function compared to standard of care (SC). Participants will engage in the interventions to which they are randomized for 6 months. The primary objective is to compare, among interventions, the 3-month change in executive function measured using the Trail Making Test A (TMTA) and B (TMTB); specifically, executive function is calculated as TMTB-TMTA to account for psychomotor speed. This primary outcome was selected based on findings from our pilot study. The secondary objectives are to compare the risk of secondary cognitive outcomes, ESKD-specific clinical outcomes, and patient-centered outcomes at 3-months and 6-months. All data collection and interventions are conducted in the dialysis center. DISCUSSION: We hypothesize that receiving intradialytic CT or ET will better preserve executive function than SC but receiving combined CT + ET, will be the most effective intervention. The current trial will be an important step in understanding how intradialytic interventions might preserve cognitive health.

trial registrationClinicaltrials.Gov (Date: 8/6/18): # NCT03616535 . Protocol Version: 10 (April 2020).

fundingNIDDK R01DK114074.

Indexed as

CognitionExecutive FunctionExercise TherapyVideo GamesCognitive DysfunctionComputers, HandheldHumansInternet-Based InterventionKidney Failure, ChronicRandomized Controlled Trials as TopicRenal DialysisTrail Making Testcognitive functionexecutive functionhemodialysisintradialytic exercise

Identifiers

PMID32883245
PMCPMC7469421
OpenAlexW3082217833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.